Osteoporosis and fractures in postmenopausal women using estrogen

Heidi Nelson, Joanne Rizzo, Emily Harris, Jane Cauley, Kristine Ensrud, Douglas C. Bauer, Eric Orwoll

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Previous studies demonstrate that postmenopausal women who use estrogen are somewhat protected from bone loss and fractures compared with nonusers, but the extent to which estrogen users remain at risk for osteoporosis and fractures is uncertain. Objective: To determine long-term probabilities for incident fractures among postmenopausal estrogen users. Methods: We examined data from the Study of Osteoporotic Fractures, a prospective cohort study with 10 years of follow-up (1986-1999). This cohort includes 8816 women 65 years and older from community settings in 4 areas of the United States. Main Outcome Measures: Hip, wrist, vertebral, and nonvertebral fractures. Results: At baseline, using criteria developed by the World Health Organization, 40% of continuous estrogen users were osteopenic and 13% were osteoporotic at the hip or spine. Although women currently using estrogen lost less bone density than past users or those who never used estrogen, all user groups on average lost bone from the hip and calcaneus. During 10 years of observation, the adjusted probability of nonvertebral fractures was 19.6% for continuous estrogen users, similar to current partial users and lower than past users and those who never used estrogen (P

Original languageEnglish (US)
Pages (from-to)2278-2284
Number of pages7
JournalArchives of Internal Medicine
Volume162
Issue number20
DOIs
StatePublished - Nov 15 2002

Fingerprint

Osteoporosis
Estrogens
Hip
Pelvic Bones
Calcaneus
Osteoporotic Fractures
Bone Fractures
Wrist
Bone Density
Spine
Cohort Studies
Observation
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Osteoporosis and fractures in postmenopausal women using estrogen. / Nelson, Heidi; Rizzo, Joanne; Harris, Emily; Cauley, Jane; Ensrud, Kristine; Bauer, Douglas C.; Orwoll, Eric.

In: Archives of Internal Medicine, Vol. 162, No. 20, 15.11.2002, p. 2278-2284.

Research output: Contribution to journalArticle

Nelson, Heidi ; Rizzo, Joanne ; Harris, Emily ; Cauley, Jane ; Ensrud, Kristine ; Bauer, Douglas C. ; Orwoll, Eric. / Osteoporosis and fractures in postmenopausal women using estrogen. In: Archives of Internal Medicine. 2002 ; Vol. 162, No. 20. pp. 2278-2284.
@article{45cc5f3955bb4f6cb77cefb3477dc9b2,
title = "Osteoporosis and fractures in postmenopausal women using estrogen",
abstract = "Background: Previous studies demonstrate that postmenopausal women who use estrogen are somewhat protected from bone loss and fractures compared with nonusers, but the extent to which estrogen users remain at risk for osteoporosis and fractures is uncertain. Objective: To determine long-term probabilities for incident fractures among postmenopausal estrogen users. Methods: We examined data from the Study of Osteoporotic Fractures, a prospective cohort study with 10 years of follow-up (1986-1999). This cohort includes 8816 women 65 years and older from community settings in 4 areas of the United States. Main Outcome Measures: Hip, wrist, vertebral, and nonvertebral fractures. Results: At baseline, using criteria developed by the World Health Organization, 40{\%} of continuous estrogen users were osteopenic and 13{\%} were osteoporotic at the hip or spine. Although women currently using estrogen lost less bone density than past users or those who never used estrogen, all user groups on average lost bone from the hip and calcaneus. During 10 years of observation, the adjusted probability of nonvertebral fractures was 19.6{\%} for continuous estrogen users, similar to current partial users and lower than past users and those who never used estrogen (P",
author = "Heidi Nelson and Joanne Rizzo and Emily Harris and Jane Cauley and Kristine Ensrud and Bauer, {Douglas C.} and Eric Orwoll",
year = "2002",
month = "11",
day = "15",
doi = "10.1001/archinte.162.20.2278",
language = "English (US)",
volume = "162",
pages = "2278--2284",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "20",

}

TY - JOUR

T1 - Osteoporosis and fractures in postmenopausal women using estrogen

AU - Nelson, Heidi

AU - Rizzo, Joanne

AU - Harris, Emily

AU - Cauley, Jane

AU - Ensrud, Kristine

AU - Bauer, Douglas C.

AU - Orwoll, Eric

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Background: Previous studies demonstrate that postmenopausal women who use estrogen are somewhat protected from bone loss and fractures compared with nonusers, but the extent to which estrogen users remain at risk for osteoporosis and fractures is uncertain. Objective: To determine long-term probabilities for incident fractures among postmenopausal estrogen users. Methods: We examined data from the Study of Osteoporotic Fractures, a prospective cohort study with 10 years of follow-up (1986-1999). This cohort includes 8816 women 65 years and older from community settings in 4 areas of the United States. Main Outcome Measures: Hip, wrist, vertebral, and nonvertebral fractures. Results: At baseline, using criteria developed by the World Health Organization, 40% of continuous estrogen users were osteopenic and 13% were osteoporotic at the hip or spine. Although women currently using estrogen lost less bone density than past users or those who never used estrogen, all user groups on average lost bone from the hip and calcaneus. During 10 years of observation, the adjusted probability of nonvertebral fractures was 19.6% for continuous estrogen users, similar to current partial users and lower than past users and those who never used estrogen (P

AB - Background: Previous studies demonstrate that postmenopausal women who use estrogen are somewhat protected from bone loss and fractures compared with nonusers, but the extent to which estrogen users remain at risk for osteoporosis and fractures is uncertain. Objective: To determine long-term probabilities for incident fractures among postmenopausal estrogen users. Methods: We examined data from the Study of Osteoporotic Fractures, a prospective cohort study with 10 years of follow-up (1986-1999). This cohort includes 8816 women 65 years and older from community settings in 4 areas of the United States. Main Outcome Measures: Hip, wrist, vertebral, and nonvertebral fractures. Results: At baseline, using criteria developed by the World Health Organization, 40% of continuous estrogen users were osteopenic and 13% were osteoporotic at the hip or spine. Although women currently using estrogen lost less bone density than past users or those who never used estrogen, all user groups on average lost bone from the hip and calcaneus. During 10 years of observation, the adjusted probability of nonvertebral fractures was 19.6% for continuous estrogen users, similar to current partial users and lower than past users and those who never used estrogen (P

UR - http://www.scopus.com/inward/record.url?scp=0037111793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037111793&partnerID=8YFLogxK

U2 - 10.1001/archinte.162.20.2278

DO - 10.1001/archinte.162.20.2278

M3 - Article

C2 - 12418942

AN - SCOPUS:0037111793

VL - 162

SP - 2278

EP - 2284

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 20

ER -