Osseous integration after fresh osteochondral allograft transplantation to the distal femur: A prospective evaluation using computed tomography

Dawson Brown, Khalid Shirzad, Stephanie A. Lavigne, Dennis Crawford

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Fresh osteochondral allograft transplantation (OCA) is an increasingly available option for patients with damage to the bone-cartilage complex of the distal femur. This study prospectively assesses osseous integration and early clinical results following fresh OCA with single or multiple cylindrical grafts to the femoral condyle. Design: Patients with grade 4 International Cartilage Repair Society (ICRS) defects of the distal femur were treated with OCA. Outcome measures were collected preoperatively and postoperatively at 6, 12, and 24 months. Computed tomography (CT) scans obtained at 6 months were used to assess degree of osseous incorporation regionally. Results: Thirty-four patients, with a mean age of 34.5 years (range, 15-61), with a mean femoral osteochondral lesion of 5.7 cm 2 (range, 1.5-15.0) due to focal osteoarthritis, osteochondritis dissecans, and avascular necrosis, are reported. Statistically significant (P <0.05) mean improvement in outcome scores at 2 years included Knee Injury and Osteoarthritis Outcomes Score (KOOS) pain, sports and recreation, quality of life, and International Knee Documentation Committee (IKDC). CT imaging indicated grafts implanted to direct weightbearing regions had >75% incorporation (20/26 grafts) compared to

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalCartilage
Volume2
Issue number4
DOIs
StatePublished - Oct 2011

Fingerprint

Cartilage
Grafts
Femur
Tomography
Allografts
Transplantation
Thigh
Osteochondritis Dissecans
Transplants
Bone and Bones
Bone
Repair
Osteoarthritis
Defects
Necrosis
Outcome Assessment (Health Care)

Keywords

  • Allograft
  • Articular cartilage
  • Bone
  • Knee

ASJC Scopus subject areas

  • Immunology and Allergy
  • Biomedical Engineering
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Osseous integration after fresh osteochondral allograft transplantation to the distal femur : A prospective evaluation using computed tomography. / Brown, Dawson; Shirzad, Khalid; Lavigne, Stephanie A.; Crawford, Dennis.

In: Cartilage, Vol. 2, No. 4, 10.2011, p. 337-345.

Research output: Contribution to journalArticle

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