Osmotic blood-brain barrier modification and combination chemotherapy: Concurrent tumor regression in areas of barrier opening and progression in brain regions distant to barrier opening

Edward Neuwelt, S. A. Hill, E. P. Frenkel

Research output: Contribution to journalArticle

57 Scopus citations


Chemotherapeutic drug delivery can be enhanced by administering drugs into the internal carotid or vertebral artery circulation after osmotic opening of the blood-brain barrier (BBB). As evidence of the clinical implications of this technique, radiographic documentation of central nervous system (CNS) tumor regression was observed in three patients concurrent with the development of new tumor nodule(s) in portions of the brain distant from the region of osmotic blood-brain barrier opening. These three patients, one with metastatic carcinoma of the breast, one with glioblastoma, and one with primary CNS lymphoma, highlight the importance of drug delivery to CNS malignancies.

Original languageEnglish (US)
Pages (from-to)362-366
Number of pages5
Issue number3
Publication statusPublished - 1984


ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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