Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery

E. A. Neuwelt, K. R. Maravilla, E. P. Frenkel, S. I. Rapaport, S. A. Hill, P. A. Barnett

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

Original languageEnglish (US)
Pages (from-to)684-688
Number of pages5
JournalUnknown Journal
Volume64
Issue number2
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery'. Together they form a unique fingerprint.

Cite this