TY - JOUR
T1 - Orphanin FQ/nociceptin
T2 - A role in pain and analgesia, but so much more
AU - Darland, Tristan
AU - Heinricher, Mary M.
AU - Grandy, David K.
N1 - Funding Information:
Supported in part by the Markey Charitable Trust (DKG) and NIDA (DKG and MMH). Special thanks to J. Mogil and J. Grisel for many thoughtful discussions and all those who shared their unpublished data with us. We would also like to thank J. Shiigi and E. Wiltshire for their help in preparing the illustrations.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - The publication of the δ opioid receptor sequence led to the cloning of three homologous receptors: the μ and κ opioid receptors, and a novel opioid-like orphan receptor. The orphan receptor's endogenous ligand, a 17- amino-acid peptide that resembles dynorphin, was named 'orphanin FQ' and 'nociceptin' (OFQ/N(1-17)). The OFQ/N(1-17) receptor is expressed widely in the nervous system, and it is becoming clear that the peptide is likely to participate in a broad range of physiological and behavioral functions. At the cellular level, OFQ/N(1-17) has much in common with the classical opioids; however, functional studies are now revealing distinct actions of this peptide. Identified only two years ago, OFQ/N(1-17) has already attracted a great deal of attention. The number and diversity of papers focused on OFQ/N(1-17) at the recent meeting of the Society for Neuroscience augur an exciting future for this new peptide.
AB - The publication of the δ opioid receptor sequence led to the cloning of three homologous receptors: the μ and κ opioid receptors, and a novel opioid-like orphan receptor. The orphan receptor's endogenous ligand, a 17- amino-acid peptide that resembles dynorphin, was named 'orphanin FQ' and 'nociceptin' (OFQ/N(1-17)). The OFQ/N(1-17) receptor is expressed widely in the nervous system, and it is becoming clear that the peptide is likely to participate in a broad range of physiological and behavioral functions. At the cellular level, OFQ/N(1-17) has much in common with the classical opioids; however, functional studies are now revealing distinct actions of this peptide. Identified only two years ago, OFQ/N(1-17) has already attracted a great deal of attention. The number and diversity of papers focused on OFQ/N(1-17) at the recent meeting of the Society for Neuroscience augur an exciting future for this new peptide.
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U2 - 10.1016/S0166-2236(97)01204-6
DO - 10.1016/S0166-2236(97)01204-6
M3 - Article
C2 - 9610886
AN - SCOPUS:0032079958
SN - 0166-2236
VL - 21
SP - 215
EP - 221
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 5
ER -