Orofacial rhabdomyosarcoma in neonates and young children

A review of literature and management of four cases

R. Chigurupati, A. Alfatooni, Robert (Bob) Myall, D. Hawkins, D. Oda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Rhabdomyosarcoma (RMS) is an aggressive malignant skeletal muscle neoplasm arising from embryonal mesenchyme. It accounts for over 50% of all pediatric soft tissue sarcomas. The head and neck region is the most common site for this tumor in children. Neonatal presentation of this tumor is rare. We present the management of one neonatal case and three additional cases of orofacial RMS in children under the age of 7 years. All four patients were seen in the department of oral and maxillofacial surgery at Children's Hospital and Regional Medical Center (CHRMC) in Seattle between 1992-2000. Three of the four cases were alveolar RMS and one was botryoid sub-type of embryonal RMS. Three patients were treated with a combination of surgery, chemotherapy and radiation, while the patient with botryoid RMS was treated with surgery and chemotherapy only. The patient with congenital RMS died at 2.5 years of age due to recurrent metastatic disease. The other three patients are alive without evidence of recurrent with a mean follow up was 5.5 years (range 2.5-8.5 years). We discuss the current management, diagnosis, biological behavior, histopathology, prognosis and survival of head and neck RMS in neonates and young children.

Original languageEnglish (US)
Pages (from-to)508-515
Number of pages8
JournalOral Oncology
Volume38
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Rhabdomyosarcoma
Case Management
Newborn Infant
Oral Surgery
Neck
Muscle Neoplasms
Head
Alveolar Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
Mesoderm
Combination Drug Therapy
Sarcoma
Neoplasms
Skeletal Muscle
Radiation
Pediatrics
Drug Therapy

Keywords

  • Neonatal
  • Orofacial
  • Pediatric
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Oncology

Cite this

Orofacial rhabdomyosarcoma in neonates and young children : A review of literature and management of four cases. / Chigurupati, R.; Alfatooni, A.; Myall, Robert (Bob); Hawkins, D.; Oda, D.

In: Oral Oncology, Vol. 38, No. 5, 2002, p. 508-515.

Research output: Contribution to journalArticle

Chigurupati, R. ; Alfatooni, A. ; Myall, Robert (Bob) ; Hawkins, D. ; Oda, D. / Orofacial rhabdomyosarcoma in neonates and young children : A review of literature and management of four cases. In: Oral Oncology. 2002 ; Vol. 38, No. 5. pp. 508-515.
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