Orofacial granulomatosis: Presentation, pathology and management of 13 cases

James J. Sciubba, Nasser Said-Al-Naief

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Background: Orofacial granulomatosis (OFG) comprises of a group of conditions, all characterized histologically by the presence of granulomatous inflammation. Methods: This diagnosis may be determined by exclusion from other conditions that may present with similar clinical and histopathologic features. These include Melkersson-Rosenthal syndrome (MRS), Miescher's cheilitis (an oligosymptomatic form of MRS), Crohn's disease, and sarcoidosis. Results: A great deal of attention has been devoted to the similarity and overlap in clinicopathologic and histomorphologic features of these conditions, suggesting that they may actually represent a spectrum within a single overarching entity. In the review of the 13 cases of OFG retrieved from the files of the Long Island Jewish Medical Center, Department of Dental Medicine, we describe their presentation, clinicopathologic features, and management. These cases comprise examples of MRS (in its oligosymptomatic forms) and Crohn's disease. The similarity, kinship, and overlap between the cases presented are clearly demonstrated. Conclusion: In addition, based upon our observations and review, we propose the notion that oral manifestations of Crohn's disease may be classified as an oligosymptomatic form of MRS.

Original languageEnglish (US)
Pages (from-to)576-585
Number of pages10
JournalJournal of Oral Pathology and Medicine
Volume32
Issue number10
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Orofacial Granulomatosis
Melkersson-Rosenthal Syndrome
Case Management
Crohn Disease
Pathology
Cheilitis
Oral Manifestations
Sarcoidosis
Islands
Tooth
Medicine
Inflammation

Keywords

  • Crohn's disease
  • Meischer's cheilitis
  • Melkersson-Rosenthal syndrome
  • Orofacial granulomatosis
  • Sarcoidosis

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Orofacial granulomatosis : Presentation, pathology and management of 13 cases. / Sciubba, James J.; Said-Al-Naief, Nasser.

In: Journal of Oral Pathology and Medicine, Vol. 32, No. 10, 11.2003, p. 576-585.

Research output: Contribution to journalArticle

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