Origin of the TEM beta lactamase gene found on plasmids

Fred Heffron, R. Sublett, R. W. Hedges, A. Jacob, S. Falkow

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Plasmid mediated resistance to penicillins and cephalosporins is almost universally associated with the elaboration of a β lactamase. Two general classes of drug resistance (R) factor mediated β lactamase are now recognized. The so called TEM type β lactamase (TEM) has a high absolute activity of 60 to 1700 mU of β lactamase per 10 9 R + bacteria against benzyl penicillin. Relative to its activity of benzyl penicillin, TEM has high activity on ampicillin and cephaloridine substrates but low activity against isoazolyl penicillins such as oxacillin and methacillin.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalJournal of Bacteriology
Volume122
Issue number1
StatePublished - 1975
Externally publishedYes

Fingerprint

beta-Lactamases
Penicillins
Plasmids
R Factors
Cephalosporin Resistance
Cephaloridine
Genes
Penicillin Resistance
Oxacillin
Ampicillin
Drug Resistance
Bacteria

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Heffron, F., Sublett, R., Hedges, R. W., Jacob, A., & Falkow, S. (1975). Origin of the TEM beta lactamase gene found on plasmids. Journal of Bacteriology, 122(1), 250-256.

Origin of the TEM beta lactamase gene found on plasmids. / Heffron, Fred; Sublett, R.; Hedges, R. W.; Jacob, A.; Falkow, S.

In: Journal of Bacteriology, Vol. 122, No. 1, 1975, p. 250-256.

Research output: Contribution to journalArticle

Heffron, F, Sublett, R, Hedges, RW, Jacob, A & Falkow, S 1975, 'Origin of the TEM beta lactamase gene found on plasmids', Journal of Bacteriology, vol. 122, no. 1, pp. 250-256.
Heffron F, Sublett R, Hedges RW, Jacob A, Falkow S. Origin of the TEM beta lactamase gene found on plasmids. Journal of Bacteriology. 1975;122(1):250-256.
Heffron, Fred ; Sublett, R. ; Hedges, R. W. ; Jacob, A. ; Falkow, S. / Origin of the TEM beta lactamase gene found on plasmids. In: Journal of Bacteriology. 1975 ; Vol. 122, No. 1. pp. 250-256.
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