Origin of the TEM beta lactamase gene found on plasmids

F. Heffron, R. Sublett, R. W. Hedges, A. Jacob, S. Falkow

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    99 Scopus citations


    Plasmid mediated resistance to penicillins and cephalosporins is almost universally associated with the elaboration of a β lactamase. Two general classes of drug resistance (R) factor mediated β lactamase are now recognized. The so called TEM type β lactamase (TEM) has a high absolute activity of 60 to 1700 mU of β lactamase per 10 9 R + bacteria against benzyl penicillin. Relative to its activity of benzyl penicillin, TEM has high activity on ampicillin and cephaloridine substrates but low activity against isoazolyl penicillins such as oxacillin and methacillin.

    Original languageEnglish (US)
    Pages (from-to)250-256
    Number of pages7
    JournalJournal of bacteriology
    Issue number1
    StatePublished - Dec 1 1975


    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology

    Cite this

    Heffron, F., Sublett, R., Hedges, R. W., Jacob, A., & Falkow, S. (1975). Origin of the TEM beta lactamase gene found on plasmids. Journal of bacteriology, 122(1), 250-256.