Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration

Agriculture & Biology

• Swiss cheese 95%
• peripheral nervous system diseases 84%
• organophosphorus compounds 68%
• esterases 57%
• phosphates 23%
• neurons 16%
• phenotype 13%
• signs and symptoms (animals and humans) 12%
• primary contact 11%
• phospholipases 7%
• acute toxicity 7%
• protein subunits 6%
• Drosophila 5%
• cell culture 5%
• rats 3%

Medicine & Life Sciences

• neurotoxic esterase 100%
• Cheese 77%
• Organophosphates 76%
• Phosphates 28%
• Diptera 21%
• Neurons 12%
• Phenotype 12%
• Phospholipases 8%
• Drosophila 6%
• Catalytic Domain 6%
• Cell Culture Techniques 5%
• Poisons 4%

Chemical Compounds

• Phosphate 31%
• Enzyme Activity 29%
• Acute Toxicity 14%
• Toxic 9%