Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Jingru Sun, Yiyong Liu, Alejandro Aballay

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalEMBO Reports
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2012

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Keywords

  • ER stress
  • OCTR-1
  • innate immunity
  • nervous system
  • unfolded protein response

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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