Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Jingru Sun; Yiyong Liu; Alejandro Aballay

doi:10.1038/embor.2012.100

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Jingru Sun, Yiyong Liu, Alejandro Aballay

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.

Original language	English (US)
Pages (from-to)	855-860
Number of pages	6
Journal	EMBO Reports
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/embor.2012.100
State	Published - Sep 2012
Externally published	Yes

Keywords

ER stress
OCTR-1
innate immunity
nervous system
unfolded protein response

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.1038/embor.2012.100

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abstract = "The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.",

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AB - The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.

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Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Abstract

Keywords

ASJC Scopus subject areas

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