Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Jingru Sun, Yiyong Liu, Alejandro Aballay

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1-a G protein-coupled catecholamine receptor expressed in neurons-suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalEMBO Reports
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Unfolded Protein Response
Chemical activation
Endoplasmic Reticulum
Proteins
Catecholamine Receptors
Protein folding
Protein Folding
Neurology
p38 Mitogen-Activated Protein Kinases
G-Protein-Coupled Receptors
GTP-Binding Proteins
Bacterial Infections
Innate Immunity
Nervous System
Neurons
Homeostasis
Down-Regulation

Keywords

  • ER stress
  • innate immunity
  • nervous system
  • OCTR-1
  • unfolded protein response

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. / Sun, Jingru; Liu, Yiyong; Aballay, Alejandro.

In: EMBO Reports, Vol. 13, No. 9, 01.09.2012, p. 855-860.

Research output: Contribution to journalReview article

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