Organ of Corti micromechanics with local electrical stimulation

Fangyi Chen, Jiefu Zheng, Niloy Choudhury, Steve Jaques, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Optical low coherence interferometry is able to both image and measure the vibration of the cellular and non-cellular structures of the organ of Corti in vivo. In this study we applied an electric current to the basal turn from a pair of electrodes, one in scala tympani and the other in scala vestibuli, at the location corresponding to ~17 kHz when interferometry measurements were made. The coherence gate of the interferometer was positioned 1) at the basilar membrane (BM) near the radial location of the outer hair cells (OHCs) (approximately ½ the width of the BM) and 2) at the reticular lamina (RL) where the OHCs are located. We confirmed that electrical stimulation with a frequency sweep (12 kHz -25 kHz) caused a mechanical BM displacement with a peak and a traveling wave-like phase delay as we reported previously using laser Doppler velocimetry and reflective beads on the BM. Reflective beads were not used in the current study. The vibration of the RL had little or no phase delay that would characterize a traveling wave. These data suggest a very high compliance system for the electrically activated cellular structure of the organ.

Original languageEnglish (US)
Title of host publicationConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
EditorsDavid T. Kemp, Nigel P. Cooper
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages135-140
Number of pages6
ISBN (Electronic)9789812833778
StatePublished - Jan 1 2008
Event10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008 - Newcastle, United Kingdom
Duration: Jul 27 2008Jul 31 2008

Publication series

NameConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008

Conference

Conference10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
CountryUnited Kingdom
CityNewcastle
Period7/27/087/31/08

Fingerprint

Basilar Membrane
Organ of Corti
Micromechanics
Outer Auditory Hair Cells
Electric Stimulation
Interferometry
Membranes
Vibration
Scala Vestibuli
Scala Tympani
Laser-Doppler Flowmetry
Electric currents
Cellular Structures
Velocity measurement
Interferometers
Compliance
Electrodes
Cells
Lasers

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

Cite this

Chen, F., Zheng, J., Choudhury, N., Jaques, S., & Nuttall, A. (2008). Organ of Corti micromechanics with local electrical stimulation. In D. T. Kemp, & N. P. Cooper (Eds.), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 (pp. 135-140). (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008). World Scientific Publishing Co. Pte Ltd.

Organ of Corti micromechanics with local electrical stimulation. / Chen, Fangyi; Zheng, Jiefu; Choudhury, Niloy; Jaques, Steve; Nuttall, Alfred.

Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. ed. / David T. Kemp; Nigel P. Cooper. World Scientific Publishing Co. Pte Ltd, 2008. p. 135-140 (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, F, Zheng, J, Choudhury, N, Jaques, S & Nuttall, A 2008, Organ of Corti micromechanics with local electrical stimulation. in DT Kemp & NP Cooper (eds), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008, World Scientific Publishing Co. Pte Ltd, pp. 135-140, 10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008, Newcastle, United Kingdom, 7/27/08.
Chen F, Zheng J, Choudhury N, Jaques S, Nuttall A. Organ of Corti micromechanics with local electrical stimulation. In Kemp DT, Cooper NP, editors, Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. World Scientific Publishing Co. Pte Ltd. 2008. p. 135-140. (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).
Chen, Fangyi ; Zheng, Jiefu ; Choudhury, Niloy ; Jaques, Steve ; Nuttall, Alfred. / Organ of Corti micromechanics with local electrical stimulation. Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008. editor / David T. Kemp ; Nigel P. Cooper. World Scientific Publishing Co. Pte Ltd, 2008. pp. 135-140 (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008).
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