Organ-confined prostate cancer: Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging

Aliya Qayyum, Fergus Coakley, Ying Lu, Jeffrey D. Olpin, Louis Wu, Benjamin M. Yeh, Peter R. Carroll, John Kurhanewicz

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

OBJECTIVE. Our aim was to determine the effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging findings in patients with organ-confined prostate cancer. MATERIALS AND METHODS. Endorectal MRI and MR spectroscopic imaging were performed in 43 patients with biopsy-proven prostate cancer before radical prostatectomy confirming organ-confined disease. For each sextant, two independent reviewers scored the degree of hemorrhage on a scale from 1 to 5 and recorded the presence or absence of capsular irregularity. A spectroscopist recorded the number of spectrally degraded voxels in the peripheral zone. The outcome variables of capsular irregularity and spectral degradation were correlated with the predictor variables of time from biopsy and degree of hemorrhage after biopsy. RESULTS. Capsular irregularity was unrelated to time from biopsy or to degree of hemorrhage. Spectral degradation was inversely related to time from biopsy (p <0.01); the mean percentage of degraded peripheral zone voxels was 18.5% within 8 weeks of biopsy compared with 7% after 8 weeks. Spectral degradation was unrelated to the degree of hemorrhage. CONCLUSION. In organ-confined prostate cancer, capsular irregularity can be seen at any time after biopsy and is independent of the degree of hemorrhage, whereas spectral degradation is seen predominantly in the first 8 weeks after biopsy. MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification.

Original languageEnglish (US)
Pages (from-to)1079-1083
Number of pages5
JournalAmerican Journal of Roentgenology
Volume183
Issue number4
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Biopsy
Hemorrhage
Prostatectomy
Guidelines

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Organ-confined prostate cancer : Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging. / Qayyum, Aliya; Coakley, Fergus; Lu, Ying; Olpin, Jeffrey D.; Wu, Louis; Yeh, Benjamin M.; Carroll, Peter R.; Kurhanewicz, John.

In: American Journal of Roentgenology, Vol. 183, No. 4, 10.2004, p. 1079-1083.

Research output: Contribution to journalArticle

Qayyum, A, Coakley, F, Lu, Y, Olpin, JD, Wu, L, Yeh, BM, Carroll, PR & Kurhanewicz, J 2004, 'Organ-confined prostate cancer: Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging', American Journal of Roentgenology, vol. 183, no. 4, pp. 1079-1083.
Qayyum, Aliya ; Coakley, Fergus ; Lu, Ying ; Olpin, Jeffrey D. ; Wu, Louis ; Yeh, Benjamin M. ; Carroll, Peter R. ; Kurhanewicz, John. / Organ-confined prostate cancer : Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging. In: American Journal of Roentgenology. 2004 ; Vol. 183, No. 4. pp. 1079-1083.
@article{9a565bc807da48818e5ad21c967b2b29,
title = "Organ-confined prostate cancer: Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging",
abstract = "OBJECTIVE. Our aim was to determine the effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging findings in patients with organ-confined prostate cancer. MATERIALS AND METHODS. Endorectal MRI and MR spectroscopic imaging were performed in 43 patients with biopsy-proven prostate cancer before radical prostatectomy confirming organ-confined disease. For each sextant, two independent reviewers scored the degree of hemorrhage on a scale from 1 to 5 and recorded the presence or absence of capsular irregularity. A spectroscopist recorded the number of spectrally degraded voxels in the peripheral zone. The outcome variables of capsular irregularity and spectral degradation were correlated with the predictor variables of time from biopsy and degree of hemorrhage after biopsy. RESULTS. Capsular irregularity was unrelated to time from biopsy or to degree of hemorrhage. Spectral degradation was inversely related to time from biopsy (p <0.01); the mean percentage of degraded peripheral zone voxels was 18.5{\%} within 8 weeks of biopsy compared with 7{\%} after 8 weeks. Spectral degradation was unrelated to the degree of hemorrhage. CONCLUSION. In organ-confined prostate cancer, capsular irregularity can be seen at any time after biopsy and is independent of the degree of hemorrhage, whereas spectral degradation is seen predominantly in the first 8 weeks after biopsy. MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification.",
author = "Aliya Qayyum and Fergus Coakley and Ying Lu and Olpin, {Jeffrey D.} and Louis Wu and Yeh, {Benjamin M.} and Carroll, {Peter R.} and John Kurhanewicz",
year = "2004",
month = "10",
language = "English (US)",
volume = "183",
pages = "1079--1083",
journal = "AJR. American journal of roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "4",

}

TY - JOUR

T1 - Organ-confined prostate cancer

T2 - Effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging

AU - Qayyum, Aliya

AU - Coakley, Fergus

AU - Lu, Ying

AU - Olpin, Jeffrey D.

AU - Wu, Louis

AU - Yeh, Benjamin M.

AU - Carroll, Peter R.

AU - Kurhanewicz, John

PY - 2004/10

Y1 - 2004/10

N2 - OBJECTIVE. Our aim was to determine the effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging findings in patients with organ-confined prostate cancer. MATERIALS AND METHODS. Endorectal MRI and MR spectroscopic imaging were performed in 43 patients with biopsy-proven prostate cancer before radical prostatectomy confirming organ-confined disease. For each sextant, two independent reviewers scored the degree of hemorrhage on a scale from 1 to 5 and recorded the presence or absence of capsular irregularity. A spectroscopist recorded the number of spectrally degraded voxels in the peripheral zone. The outcome variables of capsular irregularity and spectral degradation were correlated with the predictor variables of time from biopsy and degree of hemorrhage after biopsy. RESULTS. Capsular irregularity was unrelated to time from biopsy or to degree of hemorrhage. Spectral degradation was inversely related to time from biopsy (p <0.01); the mean percentage of degraded peripheral zone voxels was 18.5% within 8 weeks of biopsy compared with 7% after 8 weeks. Spectral degradation was unrelated to the degree of hemorrhage. CONCLUSION. In organ-confined prostate cancer, capsular irregularity can be seen at any time after biopsy and is independent of the degree of hemorrhage, whereas spectral degradation is seen predominantly in the first 8 weeks after biopsy. MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification.

AB - OBJECTIVE. Our aim was to determine the effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging findings in patients with organ-confined prostate cancer. MATERIALS AND METHODS. Endorectal MRI and MR spectroscopic imaging were performed in 43 patients with biopsy-proven prostate cancer before radical prostatectomy confirming organ-confined disease. For each sextant, two independent reviewers scored the degree of hemorrhage on a scale from 1 to 5 and recorded the presence or absence of capsular irregularity. A spectroscopist recorded the number of spectrally degraded voxels in the peripheral zone. The outcome variables of capsular irregularity and spectral degradation were correlated with the predictor variables of time from biopsy and degree of hemorrhage after biopsy. RESULTS. Capsular irregularity was unrelated to time from biopsy or to degree of hemorrhage. Spectral degradation was inversely related to time from biopsy (p <0.01); the mean percentage of degraded peripheral zone voxels was 18.5% within 8 weeks of biopsy compared with 7% after 8 weeks. Spectral degradation was unrelated to the degree of hemorrhage. CONCLUSION. In organ-confined prostate cancer, capsular irregularity can be seen at any time after biopsy and is independent of the degree of hemorrhage, whereas spectral degradation is seen predominantly in the first 8 weeks after biopsy. MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification.

UR - http://www.scopus.com/inward/record.url?scp=7944222041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7944222041&partnerID=8YFLogxK

M3 - Article

C2 - 15385308

AN - SCOPUS:7944222041

VL - 183

SP - 1079

EP - 1083

JO - AJR. American journal of roentgenology

JF - AJR. American journal of roentgenology

SN - 0361-803X

IS - 4

ER -