Orexin modulates brown adipose tissue thermogenesis

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Non-shivering thermogenesis in brown adipose tissue (BAT) plays an important role in thermoregulation. In addition, activations of BAT have important implications for energy homeostasis due to the metabolic consumption of energy reserves entailed in the production of heat in this tissue. In this conceptual overview, we describe the role of orexins/hypocretins within the central nervous system in the modulation of thermogenesis in BAT under several physiological conditions. Within this framework, we consider potential neural mechanisms underlying the pathological conditions associated with the absence of the central orexinergic modulation of BAT thermogenesis and energy expenditure. Overall, the experimental basis for our understanding of the role of central orexin in regulating body temperature and energy homeostasis provides an illustrative example that highlights several general principles and caveats that should help guide future investigations of the neurochemical regulation of thermogenesis and metabolism.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalBiomolecular Concepts
Volume3
Issue number4
DOIs
StatePublished - 2012

Fingerprint

Brown Adipose Tissue
Thermogenesis
Tissue
Homeostasis
Modulation
Body Temperature Regulation
Neurology
Body Temperature
Metabolism
Energy Metabolism
Central Nervous System
Chemical activation
Temperature

Keywords

  • cannabinoid
  • narcolepsy
  • obesity
  • stress
  • ultradian rhythm

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Cite this

Orexin modulates brown adipose tissue thermogenesis. / Madden, Christopher (Chris); Tupone, Domenico; Morrison, Shaun.

In: Biomolecular Concepts, Vol. 3, No. 4, 2012, p. 381-386.

Research output: Contribution to journalArticle

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AU - Tupone, Domenico

AU - Morrison, Shaun

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