Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change

Sarah Feldstein Ewing, Tammy Chung, Justin D. Caouette, Arielle Ketcherside, Karen A. Hudson, Francesca M. Filbey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An increasing number of studies have implicated the role of network functional connectivity in addiction. Yet, none have examined functional connectivity as a potential mechanism of adolescent behavior change. We examined the underlying neural mechanism of a promising treatment for adolescents, motivational interviewing (MI). We began by employing psychophysiological interaction (PPI) to evaluate network response in a sample of adolescent cannabis users (N=30). Next, we examined correlations between network connectivity and clinical metrics of treatment outcome. PPI analyses seeded on the orbitofrontal cortex (OFC) showed significant increases in functional connectivity across the inferior frontal gyrus (IFG), precentral gyrus, anterior and posterior cingulate gyrus, supplementary motor area (SMA), superior frontal gyrus, pallidus, caudate, and parahippocampal gyrus. Further, greater functional connectivity between the OFC and anterior cingulate/medial frontal gyrus was associated with less behavior change (e.g., greater post-treatment cannabis problems). These data support the role of the OFC network as a mechanism of adolescent treatment response.

Original languageEnglish (US)
JournalNeuroImage
DOIs
StateAccepted/In press - 2017

Fingerprint

Adolescent Behavior
Prefrontal Cortex
Gyrus Cinguli
Cannabis
Motivational Interviewing
Parahippocampal Gyrus
Motor Cortex
Frontal Lobe
Therapeutics

Keywords

  • Alcohol
  • Cannabis
  • Conjunction analysis
  • Orbitofrontal cortex
  • Psychophysiological interaction
  • Treatment

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. / Feldstein Ewing, Sarah; Chung, Tammy; Caouette, Justin D.; Ketcherside, Arielle; Hudson, Karen A.; Filbey, Francesca M.

In: NeuroImage, 2017.

Research output: Contribution to journalArticle

Feldstein Ewing, Sarah ; Chung, Tammy ; Caouette, Justin D. ; Ketcherside, Arielle ; Hudson, Karen A. ; Filbey, Francesca M. / Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. In: NeuroImage. 2017.
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