TY - JOUR
T1 - Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change
AU - Feldstein Ewing, Sarah W.
AU - Chung, Tammy
AU - Caouette, Justin D.
AU - Ketcherside, Arielle
AU - Hudson, Karen A.
AU - Filbey, Francesca M.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - An increasing number of studies have implicated the role of network functional connectivity in addiction. Yet, none have examined functional connectivity as a potential mechanism of adolescent behavior change. We examined the underlying neural mechanism of a promising treatment for adolescents, motivational interviewing (MI). We began by employing psychophysiological interaction (PPI) to evaluate network response in a sample of adolescent cannabis users (N=30). Next, we examined correlations between network connectivity and clinical metrics of treatment outcome. PPI analyses seeded on the orbitofrontal cortex (OFC) showed significant increases in functional connectivity across the inferior frontal gyrus (IFG), precentral gyrus, anterior and posterior cingulate gyrus, supplementary motor area (SMA), superior frontal gyrus, pallidus, caudate, and parahippocampal gyrus. Further, greater functional connectivity between the OFC and anterior cingulate/medial frontal gyrus was associated with less behavior change (e.g., greater post-treatment cannabis problems). These data support the role of the OFC network as a mechanism of adolescent treatment response.
AB - An increasing number of studies have implicated the role of network functional connectivity in addiction. Yet, none have examined functional connectivity as a potential mechanism of adolescent behavior change. We examined the underlying neural mechanism of a promising treatment for adolescents, motivational interviewing (MI). We began by employing psychophysiological interaction (PPI) to evaluate network response in a sample of adolescent cannabis users (N=30). Next, we examined correlations between network connectivity and clinical metrics of treatment outcome. PPI analyses seeded on the orbitofrontal cortex (OFC) showed significant increases in functional connectivity across the inferior frontal gyrus (IFG), precentral gyrus, anterior and posterior cingulate gyrus, supplementary motor area (SMA), superior frontal gyrus, pallidus, caudate, and parahippocampal gyrus. Further, greater functional connectivity between the OFC and anterior cingulate/medial frontal gyrus was associated with less behavior change (e.g., greater post-treatment cannabis problems). These data support the role of the OFC network as a mechanism of adolescent treatment response.
KW - Alcohol
KW - Cannabis
KW - Conjunction analysis
KW - Orbitofrontal cortex
KW - Psychophysiological interaction
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85008622735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008622735&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2016.12.076
DO - 10.1016/j.neuroimage.2016.12.076
M3 - Article
C2 - 28039093
AN - SCOPUS:85008622735
SN - 1053-8119
VL - 151
SP - 14
EP - 23
JO - NeuroImage
JF - NeuroImage
ER -