Orbitofacial mucormycosis with unusual pathological features

Daniel M. Albert, Robert L. Lesser, C. Robert, Z. Nicholas Zakov

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A 52-year-old man with mild diabetes and acute stem cell leukaemia developed an orbitofacial mucormycosis. Cultures showed the fungus to be Rhizopus oryzae. Vigorous treatment with amphotericin B and with other bactericidal and bacteriostatic antibiotics for a concurrent sepsis failed to suppress the infections, and the patient died. On post-mortem examination characteristic haematoxylin-staining, broad, aseptate fungal hyphae were found in the right eye, orbit, and lung. A striking and unusual feature of this case is the presence of brightly biiefringent crystals within the severely degenerated eye. These were found by histochemical staining and x-ray diffraction studies to be calcium salts of fatty acids, apparently liberated from necrotic adipose tissue of the orbit.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number10
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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