Orbitofacial mucormycosis with unusual pathological features

Daniel Albert, Robert L. Lesser, C. Robert, Z. Nicholas Zakov

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 52-year-old man with mild diabetes and acute stem cell leukaemia developed an orbitofacial mucormycosis. Cultures showed the fungus to be Rhizopus oryzae. Vigorous treatment with amphotericin B and with other bactericidal and bacteriostatic antibiotics for a concurrent sepsis failed to suppress the infections, and the patient died. On post-mortem examination characteristic haematoxylin-staining, broad, aseptate fungal hyphae were found in the right eye, orbit, and lung. A striking and unusual feature of this case is the presence of brightly biiefringent crystals within the severely degenerated eye. These were found by histochemical staining and x-ray diffraction studies to be calcium salts of fatty acids, apparently liberated from necrotic adipose tissue of the orbit.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalBritish Journal of Ophthalmology
Volume63
Issue number10
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Mucormycosis
Orbit
Staining and Labeling
Rhizopus
Hyphae
Amphotericin B
Hematoxylin
Adipose Tissue
Autopsy
Sepsis
Leukemia
Fungi
Fatty Acids
Stem Cells
Salts
X-Rays
Anti-Bacterial Agents
Calcium
Lung
Infection

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Ophthalmology

Cite this

Orbitofacial mucormycosis with unusual pathological features. / Albert, Daniel; Lesser, Robert L.; Robert, C.; Zakov, Z. Nicholas.

In: British Journal of Ophthalmology, Vol. 63, No. 10, 01.01.1979, p. 699-703.

Research output: Contribution to journalArticle

Albert, Daniel ; Lesser, Robert L. ; Robert, C. ; Zakov, Z. Nicholas. / Orbitofacial mucormycosis with unusual pathological features. In: British Journal of Ophthalmology. 1979 ; Vol. 63, No. 10. pp. 699-703.
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