Orbital Inflammatory Disease

Joseph R. Lutt, Lyndell L. Lim, Pramit M. Phal, James T. Rosenbaum

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Objectives: To familiarize rheumatologists and internists with the signs, symptoms, and management of orbital inflammatory disease (OID). Methods: A comprehensive literature review related to OID was performed and reported from the perspectives of rheumatology, ophthalmology, and radiology. Results: OID is a general term encompassing inflammatory diseases that affect some or all of the structures contained within the orbit external to the globe. Orbital involvement as a part of the initial symptom complex is not uncommon for systemic diseases such as Graves' disease, Wegener's granulomatosis, and sarcoidosis. The management of these and other causes of OID, such as idiopathic orbital inflammation (formerly known as "orbital pseudotumor"), orbital myositis, and Tolosa-Hunt syndrome frequently involves systemic immunosuppression. Before immunosuppression is considered, however, infectious and malignant causes of inflammation must be ruled out. Discussion: Rheumatologists should be familiar with the differential diagnosis of OID and often need to assist colleagues in ophthalmology and internal medicine with the management of this group of diseases.

Original languageEnglish (US)
Pages (from-to)207-222
Number of pages16
JournalSeminars in Arthritis and Rheumatism
Volume37
Issue number4
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Graves' disease
  • Wegener's granulomatosis
  • orbit
  • proptosis
  • pseudotumor
  • sarcoidosis

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

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