Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging

Gangjun Liu, Wenjuan Qi, Lingfeng Yu, Zhongping Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we analyzed the retinal and choroidal blood vasculature in the posterior segment of the human eye with optimized color Doppler and Doppler variance optical coherence tomography. Depth-resolved structure, color Doppler and Doppler variance images were compared. Blood vessels down to capillary level were able to be obtained with the optimized optical coherence color Doppler and Doppler variance method. For in-vivo imaging of human eyes, bulkmotion induced bulk phase must be identified and removed before using color Doppler method. It was found that the Doppler variance method is not sensitive to bulk motion and the method can be used without removing the bulk phase. A novel, simple and fast segmentation algorithm to indentify retinal pigment epithelium (RPE) was proposed and used to segment the retinal and choroidal layer. The algorithm was based on the detected OCT signal intensity difference between different layers. A spectrometer-based Fourier domain OCT system with a central wavelength of 890 nm and bandwidth of 150nm was used in this study. The 3-dimensional imaging volume contained 120 sequential two dimensional images with 2048 A-lines per image. The total imaging time was 12 seconds and the imaging area was 5x5 mm2.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
DOIs
StatePublished - 2011
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Fingerprint

Optical tomography
Optical Coherence Tomography
Color
tomography
color
Imaging techniques
Posterior Eye Segment
Retinal Pigments
epithelium
Retinal Pigment Epithelium
blood vessels
Blood vessels
pigments
Pigments
blood
Blood Vessels
Spectrometers
Blood
spectrometers
bandwidth

Keywords

  • laser Doppler
  • optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Liu, G., Qi, W., Yu, L., & Chen, Z. (2011). Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7889). [78890J] https://doi.org/10.1117/12.876066

Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging. / Liu, Gangjun; Qi, Wenjuan; Yu, Lingfeng; Chen, Zhongping.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011. 78890J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liu, G, Qi, W, Yu, L & Chen, Z 2011, Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7889, 78890J, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, San Francisco, CA, United States, 1/24/11. https://doi.org/10.1117/12.876066
Liu G, Qi W, Yu L, Chen Z. Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889. 2011. 78890J https://doi.org/10.1117/12.876066
Liu, Gangjun ; Qi, Wenjuan ; Yu, Lingfeng ; Chen, Zhongping. / Optimized doppler optical coherence tomography for choroidal capillary vasculature imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011.
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