Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin

John A. Viator, Guillermo Aguilar, Steven Jacques, J. Stuart Nelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Treatment of vascular skin lesions, such as port wine stain (PWS) birthmarks, uses laser energy to thermally damage the hypervascular regions in the dermis. Delivery of sufficient laser energy to the dermis can be confounded by the more superficial epidermal melanin layer, a broadband optical absorber. Laser pulses directed at skin lesions may result in excessive heating and scarring of the epidermis, resulting also in limiting the energy available to treat the dermal lesion. Cryogen spray cooling is used to selectively cool the epidermis, allowing the use of higher laser fluences which cause thermal damage in the deeper lesion, while preventing hypertrophic scarring of the epidermis. In order to optimize cryogen cooling and laser pulse parameter for treatment, the depth profile of the epidermal melanin layer and vascular lesion must be known. We use a photoacoustic probe to determine this depth profile. A Q-switched Nd:YAG laser emitting 532 nm light pulses of 4 ns duration is used to excite acoustic waves in epidermal melanin and hemoglobin in the vascular lesions via a miniature probe incorporating a piezoelectric detector. We used acoustic propagation time to determine the spatial relationship of the absorbing structures, thereby giving the necessary means to determine cryogen spurt and laser pulse timing. We present a finite difference thermal model along with data from tissue phantoms showing the effectiveness of the photoacoustic method.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages13-14
Number of pages2
Volume55
DOIs
StatePublished - 2003
Event2003 ASME International Mechanical Engineering Congress - Washington, DC., United States
Duration: Nov 15 2003Nov 21 2003

Other

Other2003 ASME International Mechanical Engineering Congress
CountryUnited States
CityWashington, DC.
Period11/15/0311/21/03

Fingerprint

Melanin
Wine
Photoacoustic effect
Laser pulses
Cooling
Lasers
Skin
Hemoglobin
Acoustics
Acoustic waves
Tissue
Detectors
Heating
Hot Temperature

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Viator, J. A., Aguilar, G., Jacques, S., & Nelson, J. S. (2003). Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 55, pp. 13-14). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2003-43169

Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin. / Viator, John A.; Aguilar, Guillermo; Jacques, Steven; Nelson, J. Stuart.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55 American Society of Mechanical Engineers (ASME), 2003. p. 13-14.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Viator, JA, Aguilar, G, Jacques, S & Nelson, JS 2003, Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 55, American Society of Mechanical Engineers (ASME), pp. 13-14, 2003 ASME International Mechanical Engineering Congress, Washington, DC., United States, 11/15/03. https://doi.org/10.1115/IMECE2003-43169
Viator JA, Aguilar G, Jacques S, Nelson JS. Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55. American Society of Mechanical Engineers (ASME). 2003. p. 13-14 https://doi.org/10.1115/IMECE2003-43169
Viator, John A. ; Aguilar, Guillermo ; Jacques, Steven ; Nelson, J. Stuart. / Optimization of cryogen spray cooling for port wine stain laser therapy using photoacoustic measurement of epidermal melanin. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55 American Society of Mechanical Engineers (ASME), 2003. pp. 13-14
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