Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates

Ilhem Messaoudi, Miranda Fischer, Jessica Warner, Buyng Park, Julie Mattison, Donald K. Ingram, Thomas Totonchy, Motomi Mori, Janko Nikolich-Žugich

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.

Original languageEnglish (US)
Pages (from-to)908-919
Number of pages12
JournalAging Cell
Volume7
Issue number6
DOIs
StatePublished - Dec 4 2008

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Keywords

  • Caloric restriction
  • Immune senescence
  • Monkeys
  • Tcells

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Messaoudi, I., Fischer, M., Warner, J., Park, B., Mattison, J., Ingram, D. K., Totonchy, T., Mori, M., & Nikolich-Žugich, J. (2008). Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell, 7(6), 908-919. https://doi.org/10.1111/j.1474-9726.2008.00440.x