Optical probes in biology

Jin Zhang, Sohum Mehta, Carsten Schultz

Research output: Book/ReportBook

1 Citation (Scopus)

Abstract

Optical probes, particularly the fluorescent varieties, enable researchers to observe cellular events in real time and with great spatial resolution. Optical Probes in Biology explores the diverse capabilities of these powerful and versatile tools and presents various approaches used to design, develop, and implement them. The book examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, membrane lipids, voltage, metal ions, metabolic signals, RNA, and histone modifications. It critically reviews the different probe designs and delves into the strategies for developing new fluorescent protein varieties with enhanced capabilities. It also covers sophisticated imaging techniques and equipment, such as intensity and lifetime-based fluorescence microscopy methods, used to visualize and track optical probes. In addition, the book goes beyond live-cell tracking to discuss the growing application of activity-based probes for performing pharmacological drug screening and probing molecular processes in living animals. It also discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers. With contributions from top international scientists, this book offers a thorough overview of the latest optical probes in cell biology and biochemistry. Both newcomers and established researchers will discover how to incorporate state-of-the-art optical probes and fluorescence imaging into their research.

Original languageEnglish (US)
PublisherCRC Press
Number of pages511
ISBN (Electronic)9781466510128
ISBN (Print)9781138199934
StatePublished - Apr 19 2016
Externally publishedYes

Fingerprint

biology
Optical Imaging
probes
Histone Code
Research Personnel
Cell Tracking
Preclinical Drug Evaluations
GTP Phosphohydrolases
Membrane Lipids
Fluorescent Dyes
Fluorescence Microscopy
Biochemistry
Cell Biology
Phosphotransferases
Metals
Pharmacology
RNA
Ions
Equipment and Supplies
Cytology

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)
  • Engineering(all)

Cite this

Zhang, J., Mehta, S., & Schultz, C. (2016). Optical probes in biology. CRC Press.

Optical probes in biology. / Zhang, Jin; Mehta, Sohum; Schultz, Carsten.

CRC Press, 2016. 511 p.

Research output: Book/ReportBook

Zhang, J, Mehta, S & Schultz, C 2016, Optical probes in biology. CRC Press.
Zhang J, Mehta S, Schultz C. Optical probes in biology. CRC Press, 2016. 511 p.
Zhang, Jin ; Mehta, Sohum ; Schultz, Carsten. / Optical probes in biology. CRC Press, 2016. 511 p.
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