Optical monitoring of chemical reactions by fluorescence in turbid media

Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The observation of fluorescence in a tissue offers a method of real-time monitoring of chemical reactions when one of the reagents or products in fluorescent. This paper discusses how tissue optics affects one's observation of fluorescence in a turbid medium such as tissue. An experimental example is also shown: the photobleaching of a photosensitizer molecule (protoporphyrin IX) within rat tumors. A simple algorithm (Gardner et al., 1993) is given which enables the corrections for tissue optics.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages73-83
Number of pages11
ISBN (Print)0819411094
StatePublished - Jan 1 1993
EventLaser-Tissue Interaction IV - Los Angeles, CA, USA
Duration: Jan 18 1993Jan 20 1993

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1882
ISSN (Print)0277-786X

Other

OtherLaser-Tissue Interaction IV
CityLos Angeles, CA, USA
Period1/18/931/20/93

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Jacques, S. L. (1993). Optical monitoring of chemical reactions by fluorescence in turbid media. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 73-83). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1882). Publ by Society of Photo-Optical Instrumentation Engineers.