Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment

Ruikang K. Wang, Lin An, Spencer Saunders, David J. Wilson

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

In this paper, we demonstrate that the optical microangiography (OAMG) is capable of depth-resolved imaging of directional blood perfusion within both retinal and choroid in the posterior segment of human eye. The study uses an OMAG system operating at 840 nm with an imaging speed at 27,000 A-scans per second. Sequentially registered multiple OMAG projection maps of small areas (∼1 mm×1 mm) are combined to provide directional blood flow images for a larger field of view. It takes ∼3.7 sec to image a small area (1 ×1 mm 2), and ∼2.5 min for a larger field (3×3 mm 2). Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology.

Original languageEnglish (US)
Article number020502
JournalJournal of biomedical optics
Volume15
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Ophthalmology
  • Optical coherence tomography
  • Optical microangiography
  • Retinal and choroidal blood perfusion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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