Optical manipulation of objects in microfluidic devices

Erhan Ata, Aaron L. Birkbeck, Mihrimah Ozkan, Cengiz S. Ozkan, Richard Flynn, Mark Wang, Sadik Esener

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an "optical handle". Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalMaterials Research Society Symposium - Proceedings
Volume729
DOIs
StatePublished - Jan 1 2002
EventBioMEMS and Bionanotechnology - San Francisco, CA, United States
Duration: Apr 1 2002Apr 3 2002

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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