Optical manipulation of objects in microfluidic devices

Erhan Ata, Aaron L. Birkbeck, Mihrimah Ozkan, Cengiz S. Ozkan, Richard Flynn, Mark Wang, Sadik Esener

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an "optical handle". Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalUnknown Journal
Volume729
StatePublished - 2002
Externally publishedYes

Fingerprint

Lab-On-A-Chip Devices
Fluidics
Microfluidics
Cytology
Optical Tweezers
Elastomers
Optical tweezers
Syringes
Equipment and Supplies
Polystyrenes
Surface emitting lasers
Polydimethylsiloxane
Photoresists
Drug Discovery
Photons
Molding
Cell Biology
Pumps
Research

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Ata, E., Birkbeck, A. L., Ozkan, M., Ozkan, C. S., Flynn, R., Wang, M., & Esener, S. (2002). Optical manipulation of objects in microfluidic devices. Unknown Journal, 729, 9-15.

Optical manipulation of objects in microfluidic devices. / Ata, Erhan; Birkbeck, Aaron L.; Ozkan, Mihrimah; Ozkan, Cengiz S.; Flynn, Richard; Wang, Mark; Esener, Sadik.

In: Unknown Journal, Vol. 729, 2002, p. 9-15.

Research output: Contribution to journalArticle

Ata, E, Birkbeck, AL, Ozkan, M, Ozkan, CS, Flynn, R, Wang, M & Esener, S 2002, 'Optical manipulation of objects in microfluidic devices', Unknown Journal, vol. 729, pp. 9-15.
Ata E, Birkbeck AL, Ozkan M, Ozkan CS, Flynn R, Wang M et al. Optical manipulation of objects in microfluidic devices. Unknown Journal. 2002;729:9-15.
Ata, Erhan ; Birkbeck, Aaron L. ; Ozkan, Mihrimah ; Ozkan, Cengiz S. ; Flynn, Richard ; Wang, Mark ; Esener, Sadik. / Optical manipulation of objects in microfluidic devices. In: Unknown Journal. 2002 ; Vol. 729. pp. 9-15.
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