Optical manipulation of objects in microfluidic devices

Erhan Ata; Aaron L. Birkbeck; Mihrimah Ozkan; Cengiz S. Ozkan; Richard Flynn; Mark Wang; Sadik Esener

doi:10.1557/proc-729-u1.6

Optical manipulation of objects in microfluidic devices

Erhan Ata, Aaron L. Birkbeck, Mihrimah Ozkan, Cengiz S. Ozkan, Richard Flynn, Mark Wang, Sadik Esener

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an "optical handle". Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Materials Research Society Symposium - Proceedings
Volume	729
DOIs	https://doi.org/10.1557/proc-729-u1.6
State	Published - 2002
Externally published	Yes
Event	BioMEMS and Bionanotechnology - San Francisco, CA, United States Duration: Apr 1 2002 → Apr 3 2002

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1557/proc-729-u1.6

Cite this

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title = "Optical manipulation of objects in microfluidic devices",

abstract = "In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an {"}optical handle{"}. Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.",

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AU - Ata, Erhan

AU - Birkbeck, Aaron L.

AU - Ozkan, Mihrimah

AU - Ozkan, Cengiz S.

AU - Flynn, Richard

AU - Wang, Mark

AU - Esener, Sadik

PY - 2002

Y1 - 2002

N2 - In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an "optical handle". Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

AB - In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an "optical handle". Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

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DO - 10.1557/proc-729-u1.6

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JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - BioMEMS and Bionanotechnology

Y2 - 1 April 2002 through 3 April 2002

ER -

Optical manipulation of objects in microfluidic devices

Abstract

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