Optical imaging of cortical networks via intracortical microstimulation

Andrea A. Brock, Robert M. Friedman, Reuben H. Fan, Anna Roe

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is known about how different nodes in the cortical network interact during perceptual processing and motor behavior. To study cortical network function we examined whether the optical imaging of intrinsic signals (OIS) reveals the functional patterns of activity evoked by electrical cortical microstimulation. We examined the effects of current amplitude, train duration, and depth of cortical stimulation on the hemodynamic response to electrical microstimulation (250-Hz train, 0.4-ms pulse duration) in anesthetized New World monkey somatosensory cortex. Electrical stimulation elicited a restricted cortical response that varied according to stimulation parameters and electrode depth. Higher currents of stimulation recruited more areas of cortex than smaller currents. The largest cortical responses were seen when stimulation was delivered around cortical layer 4. Distinct local patches of activation, highly suggestive of local projections, around the site of stimulation were observed at different depths of stimulation. Thus we find that specific electrical stimulation parameters can elicit activation of single cortical columns and their associated columnar networks, reminiscent of anatomically labeled networks. This novel functional tract tracing method will open new avenues for investigating relationships of local cortical organization.

Original languageEnglish (US)
Pages (from-to)2670-2678
Number of pages9
JournalJournal of Neurophysiology
Volume110
Issue number11
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Optical Imaging
Electric Stimulation
Platyrrhini
Somatosensory Cortex
Cerebral Cortex
Electrodes
Hemodynamics
Brain

Keywords

  • Electrical microstimulation
  • Intrinsic signal optical imaging

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Optical imaging of cortical networks via intracortical microstimulation. / Brock, Andrea A.; Friedman, Robert M.; Fan, Reuben H.; Roe, Anna.

In: Journal of Neurophysiology, Vol. 110, No. 11, 01.12.2013, p. 2670-2678.

Research output: Contribution to journalArticle

Brock, Andrea A. ; Friedman, Robert M. ; Fan, Reuben H. ; Roe, Anna. / Optical imaging of cortical networks via intracortical microstimulation. In: Journal of Neurophysiology. 2013 ; Vol. 110, No. 11. pp. 2670-2678.
@article{68bac5e622e34a82b16b4ec05e860b21,
title = "Optical imaging of cortical networks via intracortical microstimulation",
abstract = "Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is known about how different nodes in the cortical network interact during perceptual processing and motor behavior. To study cortical network function we examined whether the optical imaging of intrinsic signals (OIS) reveals the functional patterns of activity evoked by electrical cortical microstimulation. We examined the effects of current amplitude, train duration, and depth of cortical stimulation on the hemodynamic response to electrical microstimulation (250-Hz train, 0.4-ms pulse duration) in anesthetized New World monkey somatosensory cortex. Electrical stimulation elicited a restricted cortical response that varied according to stimulation parameters and electrode depth. Higher currents of stimulation recruited more areas of cortex than smaller currents. The largest cortical responses were seen when stimulation was delivered around cortical layer 4. Distinct local patches of activation, highly suggestive of local projections, around the site of stimulation were observed at different depths of stimulation. Thus we find that specific electrical stimulation parameters can elicit activation of single cortical columns and their associated columnar networks, reminiscent of anatomically labeled networks. This novel functional tract tracing method will open new avenues for investigating relationships of local cortical organization.",
keywords = "Electrical microstimulation, Intrinsic signal optical imaging",
author = "Brock, {Andrea A.} and Friedman, {Robert M.} and Fan, {Reuben H.} and Anna Roe",
year = "2013",
month = "12",
day = "1",
doi = "10.1152/jn.00879.2012",
language = "English (US)",
volume = "110",
pages = "2670--2678",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "11",

}

TY - JOUR

T1 - Optical imaging of cortical networks via intracortical microstimulation

AU - Brock, Andrea A.

AU - Friedman, Robert M.

AU - Fan, Reuben H.

AU - Roe, Anna

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is known about how different nodes in the cortical network interact during perceptual processing and motor behavior. To study cortical network function we examined whether the optical imaging of intrinsic signals (OIS) reveals the functional patterns of activity evoked by electrical cortical microstimulation. We examined the effects of current amplitude, train duration, and depth of cortical stimulation on the hemodynamic response to electrical microstimulation (250-Hz train, 0.4-ms pulse duration) in anesthetized New World monkey somatosensory cortex. Electrical stimulation elicited a restricted cortical response that varied according to stimulation parameters and electrode depth. Higher currents of stimulation recruited more areas of cortex than smaller currents. The largest cortical responses were seen when stimulation was delivered around cortical layer 4. Distinct local patches of activation, highly suggestive of local projections, around the site of stimulation were observed at different depths of stimulation. Thus we find that specific electrical stimulation parameters can elicit activation of single cortical columns and their associated columnar networks, reminiscent of anatomically labeled networks. This novel functional tract tracing method will open new avenues for investigating relationships of local cortical organization.

AB - Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is known about how different nodes in the cortical network interact during perceptual processing and motor behavior. To study cortical network function we examined whether the optical imaging of intrinsic signals (OIS) reveals the functional patterns of activity evoked by electrical cortical microstimulation. We examined the effects of current amplitude, train duration, and depth of cortical stimulation on the hemodynamic response to electrical microstimulation (250-Hz train, 0.4-ms pulse duration) in anesthetized New World monkey somatosensory cortex. Electrical stimulation elicited a restricted cortical response that varied according to stimulation parameters and electrode depth. Higher currents of stimulation recruited more areas of cortex than smaller currents. The largest cortical responses were seen when stimulation was delivered around cortical layer 4. Distinct local patches of activation, highly suggestive of local projections, around the site of stimulation were observed at different depths of stimulation. Thus we find that specific electrical stimulation parameters can elicit activation of single cortical columns and their associated columnar networks, reminiscent of anatomically labeled networks. This novel functional tract tracing method will open new avenues for investigating relationships of local cortical organization.

KW - Electrical microstimulation

KW - Intrinsic signal optical imaging

UR - http://www.scopus.com/inward/record.url?scp=84888606690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888606690&partnerID=8YFLogxK

U2 - 10.1152/jn.00879.2012

DO - 10.1152/jn.00879.2012

M3 - Article

VL - 110

SP - 2670

EP - 2678

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 11

ER -