Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomies

Daniel S. Gareau, Frederic Truffer, Kyle A. Perry, Thai H. Pham, Charles Enestvedt, James Dolan, John Hunter, Steven Jacques

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenation, and that intraoperative gastric ischemia will correlate with the development of anastomotic complications. A simple optical fiber probe spectrometer is designed for nondestructive laparoscopic measurement of blood content and hemoglobin oxygen saturation in the stomach tissue microvasculature during human esophagectomies. In 22 patients, the probe measured the light transport in stomach tissue between two fibers spaced 3-mm apart (500- to 650-nm wavelength range). The stomach tissue site of measurement becomes the site of a gastroesophageal anastamosis following excision of the cancerous esophagus and surgical ligation of two of the three gastric arteries that provide blood perfusion to the anastamosis. Measurements are made at each of five steps throughout the surgery. The resting baseline saturation is 0.51±0.15 and decreases to 0.35±0.20 with ligation. Seven patients develop anastomotic complications, and a decreased saturation at either of the last two steps (completion of conduit and completion of anastamosis) is predictive of complication with a sensitivity of 0.71 when the specificity equaled 0.71.

Original languageEnglish (US)
Article number061712
JournalJournal of Biomedical Optics
Volume15
Issue number6
DOIs
StatePublished - Nov 2010

Fingerprint

Oxygenation
oxygenation
Optical fibers
optical fibers
stomach
Spectroscopy
Tissue
Monitoring
probes
Hemoglobin oxygen saturation
Blood
ischemia
spectroscopy
saturation
blood
Surgery
Fiber optics
Spectrometers
esophagus
hemoglobin

Keywords

  • diffuse reflectance spectroscopy
  • optical fibers
  • oxygen saturation
  • surgery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomies. / Gareau, Daniel S.; Truffer, Frederic; Perry, Kyle A.; Pham, Thai H.; Enestvedt, Charles; Dolan, James; Hunter, John; Jacques, Steven.

In: Journal of Biomedical Optics, Vol. 15, No. 6, 061712, 11.2010.

Research output: Contribution to journalArticle

@article{6c9d40b49d714fd19c5cf1c03c7cda6c,
title = "Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomies",
abstract = "Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenation, and that intraoperative gastric ischemia will correlate with the development of anastomotic complications. A simple optical fiber probe spectrometer is designed for nondestructive laparoscopic measurement of blood content and hemoglobin oxygen saturation in the stomach tissue microvasculature during human esophagectomies. In 22 patients, the probe measured the light transport in stomach tissue between two fibers spaced 3-mm apart (500- to 650-nm wavelength range). The stomach tissue site of measurement becomes the site of a gastroesophageal anastamosis following excision of the cancerous esophagus and surgical ligation of two of the three gastric arteries that provide blood perfusion to the anastamosis. Measurements are made at each of five steps throughout the surgery. The resting baseline saturation is 0.51±0.15 and decreases to 0.35±0.20 with ligation. Seven patients develop anastomotic complications, and a decreased saturation at either of the last two steps (completion of conduit and completion of anastamosis) is predictive of complication with a sensitivity of 0.71 when the specificity equaled 0.71.",
keywords = "diffuse reflectance spectroscopy, optical fibers, oxygen saturation, surgery",
author = "Gareau, {Daniel S.} and Frederic Truffer and Perry, {Kyle A.} and Pham, {Thai H.} and Charles Enestvedt and James Dolan and John Hunter and Steven Jacques",
year = "2010",
month = "11",
doi = "10.1117/1.3512149",
language = "English (US)",
volume = "15",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "6",

}

TY - JOUR

T1 - Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomies

AU - Gareau, Daniel S.

AU - Truffer, Frederic

AU - Perry, Kyle A.

AU - Pham, Thai H.

AU - Enestvedt, Charles

AU - Dolan, James

AU - Hunter, John

AU - Jacques, Steven

PY - 2010/11

Y1 - 2010/11

N2 - Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenation, and that intraoperative gastric ischemia will correlate with the development of anastomotic complications. A simple optical fiber probe spectrometer is designed for nondestructive laparoscopic measurement of blood content and hemoglobin oxygen saturation in the stomach tissue microvasculature during human esophagectomies. In 22 patients, the probe measured the light transport in stomach tissue between two fibers spaced 3-mm apart (500- to 650-nm wavelength range). The stomach tissue site of measurement becomes the site of a gastroesophageal anastamosis following excision of the cancerous esophagus and surgical ligation of two of the three gastric arteries that provide blood perfusion to the anastamosis. Measurements are made at each of five steps throughout the surgery. The resting baseline saturation is 0.51±0.15 and decreases to 0.35±0.20 with ligation. Seven patients develop anastomotic complications, and a decreased saturation at either of the last two steps (completion of conduit and completion of anastamosis) is predictive of complication with a sensitivity of 0.71 when the specificity equaled 0.71.

AB - Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenation, and that intraoperative gastric ischemia will correlate with the development of anastomotic complications. A simple optical fiber probe spectrometer is designed for nondestructive laparoscopic measurement of blood content and hemoglobin oxygen saturation in the stomach tissue microvasculature during human esophagectomies. In 22 patients, the probe measured the light transport in stomach tissue between two fibers spaced 3-mm apart (500- to 650-nm wavelength range). The stomach tissue site of measurement becomes the site of a gastroesophageal anastamosis following excision of the cancerous esophagus and surgical ligation of two of the three gastric arteries that provide blood perfusion to the anastamosis. Measurements are made at each of five steps throughout the surgery. The resting baseline saturation is 0.51±0.15 and decreases to 0.35±0.20 with ligation. Seven patients develop anastomotic complications, and a decreased saturation at either of the last two steps (completion of conduit and completion of anastamosis) is predictive of complication with a sensitivity of 0.71 when the specificity equaled 0.71.

KW - diffuse reflectance spectroscopy

KW - optical fibers

KW - oxygen saturation

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=79955976645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955976645&partnerID=8YFLogxK

U2 - 10.1117/1.3512149

DO - 10.1117/1.3512149

M3 - Article

C2 - 21198160

AN - SCOPUS:79955976645

VL - 15

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 6

M1 - 061712

ER -