Abstract
Susac's syndrome is an autoimmune endotheliopathy with predilection for brain, retina and cochlea (Susac, 1994). Optical coherence tomography (OCT) is a non-invasive method, which is increasingly used in the diagnosis of retinal as well as primary central nervous system diseases. OCT is suggested as a useful diagnostic tool in differentiating Susac's syndrome from multiple sclerosis (MS) (Brandt et al., 2012). This report demonstrates the OCT findings in 3 patients with Susac's syndrome in different stages of the disease. The OCT demonstrated decreased retinal nerve fiber layer (RNFL) thickness, which was patchy in nature and more prominent in the nasal quadrants. We also observed loss of the normal foveal contour, which is uncharacteristic for MS. The extent and degree of the OCT abnormalities in our patients correlated with the stage and severity of the disease and correlated with the findings on the visual field studies. We confirm that OCT is a useful diagnostic tool in Susac's syndrome and helps to differentiate it from MS. Furthermore, OCT may be a non-invasive alternative to fluorescein angiography in longitudinal follow up of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 110-116 |
| Number of pages | 7 |
| Journal | Multiple Sclerosis and Related Disorders |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
Fingerprint
Keywords
- Branch retinal artery occlusion
- BRAO
- Multiple sclerosis
- OCT Optical coherence tomography
- Susac's syndrome
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Optical coherence tomography in Susac's syndrome. / Bernard, Jacqueline; Romero, Rebecca; Agrawal, Khushboo; Jager, Rama; Rezania, Kourosh.
In: Multiple Sclerosis and Related Disorders, Vol. 3, No. 1, 01.01.2014, p. 110-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optical coherence tomography in Susac's syndrome
AU - Bernard, Jacqueline
AU - Romero, Rebecca
AU - Agrawal, Khushboo
AU - Jager, Rama
AU - Rezania, Kourosh
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Susac's syndrome is an autoimmune endotheliopathy with predilection for brain, retina and cochlea (Susac, 1994). Optical coherence tomography (OCT) is a non-invasive method, which is increasingly used in the diagnosis of retinal as well as primary central nervous system diseases. OCT is suggested as a useful diagnostic tool in differentiating Susac's syndrome from multiple sclerosis (MS) (Brandt et al., 2012). This report demonstrates the OCT findings in 3 patients with Susac's syndrome in different stages of the disease. The OCT demonstrated decreased retinal nerve fiber layer (RNFL) thickness, which was patchy in nature and more prominent in the nasal quadrants. We also observed loss of the normal foveal contour, which is uncharacteristic for MS. The extent and degree of the OCT abnormalities in our patients correlated with the stage and severity of the disease and correlated with the findings on the visual field studies. We confirm that OCT is a useful diagnostic tool in Susac's syndrome and helps to differentiate it from MS. Furthermore, OCT may be a non-invasive alternative to fluorescein angiography in longitudinal follow up of these patients.
AB - Susac's syndrome is an autoimmune endotheliopathy with predilection for brain, retina and cochlea (Susac, 1994). Optical coherence tomography (OCT) is a non-invasive method, which is increasingly used in the diagnosis of retinal as well as primary central nervous system diseases. OCT is suggested as a useful diagnostic tool in differentiating Susac's syndrome from multiple sclerosis (MS) (Brandt et al., 2012). This report demonstrates the OCT findings in 3 patients with Susac's syndrome in different stages of the disease. The OCT demonstrated decreased retinal nerve fiber layer (RNFL) thickness, which was patchy in nature and more prominent in the nasal quadrants. We also observed loss of the normal foveal contour, which is uncharacteristic for MS. The extent and degree of the OCT abnormalities in our patients correlated with the stage and severity of the disease and correlated with the findings on the visual field studies. We confirm that OCT is a useful diagnostic tool in Susac's syndrome and helps to differentiate it from MS. Furthermore, OCT may be a non-invasive alternative to fluorescein angiography in longitudinal follow up of these patients.
KW - Branch retinal artery occlusion
KW - BRAO
KW - Multiple sclerosis
KW - OCT Optical coherence tomography
KW - Susac's syndrome
UR - http://www.scopus.com/inward/record.url?scp=84884292001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884292001&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2013.05.005
DO - 10.1016/j.msard.2013.05.005
M3 - Article
AN - SCOPUS:84884292001
VL - 3
SP - 110
EP - 116
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
IS - 1
ER -