Optical coherence tomography findings in autoimmune retinopathy

Azin Abazari, Souha S. Allam, Grazyna Adamus, Nicola G. Ghazi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To report optical coherence tomography (OCT) features of patients with autoimmune retinopathy. Design: Consecutive case series. Method: Eight patients who presented with unexplained loss of central vision, visual field defects, and/or photopsia were diagnosed with autoimmune retinopathy based on clinical features, electroretinogram (ERG) findings, and serum antiretinal antibody analysis. All patients underwent OCT testing of the macula and nerve fiber layer (NFL). Results: Outer retinal abnormalities and/or decreased macular thickness on OCT were seen in all patients. Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). In all but 1 patient, loss of the photoreceptor layer or disruption of the photoreceptor outer and inner segment junction was noted. Three patients showed only mild to moderate focal NFL loss. Conclusions: Retinal atrophy and reduced macular thickness on OCT are predominant features in patients with autoimmune retinopathy. OCT provides objective measures of retinal damage and may offer clues toward understanding the mechanism of visual dysfunction and the diagnosis of autoimmune retinopathy.

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Volume153
Issue number4
DOIs
StatePublished - Apr 2012

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Optical Coherence Tomography
Nerve Fibers
Visual Fields
Atrophy
Antibodies
Serum

ASJC Scopus subject areas

  • Ophthalmology

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Optical coherence tomography findings in autoimmune retinopathy. / Abazari, Azin; Allam, Souha S.; Adamus, Grazyna; Ghazi, Nicola G.

In: American Journal of Ophthalmology, Vol. 153, No. 4, 04.2012.

Research output: Contribution to journalArticle

Abazari, Azin ; Allam, Souha S. ; Adamus, Grazyna ; Ghazi, Nicola G. / Optical coherence tomography findings in autoimmune retinopathy. In: American Journal of Ophthalmology. 2012 ; Vol. 153, No. 4.
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