Optical coherence tomography findings during pegaptanib therapy for neovascular age-related macular degeneration

Geoffrey G. Emerson, Christina J. Flaxel, Andreas K. Lauer, J. Timothy Stout, M. Vaughn Emerson, Susan Nolte, David J. Wilson, Michael L. Klein

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

BACKGROUND: To evaluate macular thickness measured by optical coherence tomography (OCT) during pegaptanib therapy for neovascular age-related macular degeneration (AMD). METHODS: For this prospective, nonrandomized, observational case series, 41 eyes from 41 patients with neovascular AMD received intravitreous pegaptanib (1 mg) injections repeated every 6 weeks. The primary outcome measure was central foveal thickness measured by OCT. Secondary outcomes were fluorescein angiographic leakage and visual acuity. RESULTS: Mean thickness of the central area on OCT decreased from 340 ± 24 μm to 299 ± 14 μm after 12 weeks of pegaptanib injections. This represents a reduction in thickening of 32%. Fluorescein angiograms with definite leakage decreased from 100% to 81%, and mean visual acuity decreased from 20/116 to 20/120. CONCLUSIONS: Intravitreal injections of pegaptanib at 6-week intervals result in a moderate reduction of central foveal thickness in eyes with subfoveal neovascular AMD. This presents a modest effect relative to that reported with other anti-angiogenic agents.

Original languageEnglish (US)
Pages (from-to)724-729
Number of pages6
JournalRetina
Volume27
Issue number6
DOIs
StatePublished - Jul 1 2007

Keywords

  • Age-related macular degeneration
  • Choroidal neovascularization
  • Macugen
  • Optical coherence tomography
  • Pegaptanib
  • Retinal edema

ASJC Scopus subject areas

  • Ophthalmology

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