Abstract
Aims: Study the choroidal neovascularization (CNV) morphological evolution after treatment using optical coherence tomography angiography (OCTA). Method: We used Optovue XR Avanti, with split-spectrum amplitude-decorrelation angiography algorithm. Results: OCT Angiography allows to recognize better the CNV type. In our series all our cases seem to follow a 45 to 60 days cycle, after intra vitreal injection. After each injection a pruning of smaller vessels is seen immediately (after 24 hours) that increases for 6 to 12 days when it reaches a maximum. It is followed by a reopening or new sprouting of the vessels 20 to 50 days later. The later cycles seem longer. Our results on early CNV evolution seem to confirm previous observations of CNV abnormalization and arterialization. Pruning the small peripheral branches seems to strengthen the trunk. In OCTA, closing terminal vessels (anti-VEGF effects) seems to cause an increased flow in trunk after the CNV reactivation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-85 |
| Number of pages | 9 |
| Journal | Developments in Ophthalmology |
| Volume | 56 |
| DOIs | |
| State | Published - 2016 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Early Response after Treatment. / Lumbroso, Bruno; Rispoli, Marco; Savastano, Maria Cristina; Yali, Jia; Tan, Ou; Huang, David.
In: Developments in Ophthalmology, Vol. 56, 2016, p. 77-85.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Early Response after Treatment
AU - Lumbroso, Bruno
AU - Rispoli, Marco
AU - Savastano, Maria Cristina
AU - Yali, Jia
AU - Tan, Ou
AU - Huang, David
PY - 2016
Y1 - 2016
N2 - Aims: Study the choroidal neovascularization (CNV) morphological evolution after treatment using optical coherence tomography angiography (OCTA). Method: We used Optovue XR Avanti, with split-spectrum amplitude-decorrelation angiography algorithm. Results: OCT Angiography allows to recognize better the CNV type. In our series all our cases seem to follow a 45 to 60 days cycle, after intra vitreal injection. After each injection a pruning of smaller vessels is seen immediately (after 24 hours) that increases for 6 to 12 days when it reaches a maximum. It is followed by a reopening or new sprouting of the vessels 20 to 50 days later. The later cycles seem longer. Our results on early CNV evolution seem to confirm previous observations of CNV abnormalization and arterialization. Pruning the small peripheral branches seems to strengthen the trunk. In OCTA, closing terminal vessels (anti-VEGF effects) seems to cause an increased flow in trunk after the CNV reactivation.
AB - Aims: Study the choroidal neovascularization (CNV) morphological evolution after treatment using optical coherence tomography angiography (OCTA). Method: We used Optovue XR Avanti, with split-spectrum amplitude-decorrelation angiography algorithm. Results: OCT Angiography allows to recognize better the CNV type. In our series all our cases seem to follow a 45 to 60 days cycle, after intra vitreal injection. After each injection a pruning of smaller vessels is seen immediately (after 24 hours) that increases for 6 to 12 days when it reaches a maximum. It is followed by a reopening or new sprouting of the vessels 20 to 50 days later. The later cycles seem longer. Our results on early CNV evolution seem to confirm previous observations of CNV abnormalization and arterialization. Pruning the small peripheral branches seems to strengthen the trunk. In OCTA, closing terminal vessels (anti-VEGF effects) seems to cause an increased flow in trunk after the CNV reactivation.
UR - http://www.scopus.com/inward/record.url?scp=84962425757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962425757&partnerID=8YFLogxK
U2 - 10.1159/000442782
DO - 10.1159/000442782
M3 - Article
C2 - 27022967
AN - SCOPUS:84962425757
VL - 56
SP - 77
EP - 85
JO - Developments in Ophthalmology
JF - Developments in Ophthalmology
SN - 0250-3751
ER -