Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma

Shunhua Zhang, Chan Wu, Liang Liu, Jia Yali, Yao Zhang, Yang Zhang, Hua Zhang, Yong Zhong, David Huang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle-closure glaucoma (PACG). Design Case-control study. Methods Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field (VF). Spectral-domain optical coherence tomography (SD-OCT) was used to obtain both structural OCT and OCT angiography (OCTA). Structural OCT scans provided thickness measurements of the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC). OCTA was used to measure all-plexus peripapillary retinal VD. Results In unaffected eyes, a dense microvascular network surrounded the disc on all-plexus retinal OCTA. The vascular network was visibly attenuated and focal capillary dropout was evident in acute PACG eyes. The peripapillary VD in acute PACG eyes was 66.6% ± 17.3% (mean ± standard deviation), which was significantly (P <.01) reduced compared to 87.2% ± 8.6% in the unaffected eyes. In acute PACG eyes, peripapillary retinal VD was positively correlated with RNFL and GCC thicknesses (P <.001 each) and negatively correlated with VF mean deviation (P =.002) and cup-to-disc ratio (P =.0064). In unaffected eyes, there were no correlations between peripapillary retinal VD and glaucoma-related parameters. Conclusions In acute PACG eyes, peripapillary retinal VD decreased significantly compared with the contralateral unaffected eyes. Peripapillary retinal VD was significantly correlated with other glaucomatous changes.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume182
DOIs
StatePublished - Oct 1 2017

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Angle Closure Glaucoma
Optical Coherence Tomography
Retina
Angiography
Retinal Vessels
Visual Fields
Nerve Fibers
Ganglia
Microvessels
Intraocular Pressure
Glaucoma
Visual Acuity
Blood Vessels
Case-Control Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma. / Zhang, Shunhua; Wu, Chan; Liu, Liang; Yali, Jia; Zhang, Yao; Zhang, Yang; Zhang, Hua; Zhong, Yong; Huang, David.

In: American Journal of Ophthalmology, Vol. 182, 01.10.2017, p. 194-200.

Research output: Contribution to journalArticle

Zhang, Shunhua ; Wu, Chan ; Liu, Liang ; Yali, Jia ; Zhang, Yao ; Zhang, Yang ; Zhang, Hua ; Zhong, Yong ; Huang, David. / Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma. In: American Journal of Ophthalmology. 2017 ; Vol. 182. pp. 194-200.
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abstract = "Purpose To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle-closure glaucoma (PACG). Design Case-control study. Methods Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field (VF). Spectral-domain optical coherence tomography (SD-OCT) was used to obtain both structural OCT and OCT angiography (OCTA). Structural OCT scans provided thickness measurements of the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC). OCTA was used to measure all-plexus peripapillary retinal VD. Results In unaffected eyes, a dense microvascular network surrounded the disc on all-plexus retinal OCTA. The vascular network was visibly attenuated and focal capillary dropout was evident in acute PACG eyes. The peripapillary VD in acute PACG eyes was 66.6{\%} ± 17.3{\%} (mean ± standard deviation), which was significantly (P <.01) reduced compared to 87.2{\%} ± 8.6{\%} in the unaffected eyes. In acute PACG eyes, peripapillary retinal VD was positively correlated with RNFL and GCC thicknesses (P <.001 each) and negatively correlated with VF mean deviation (P =.002) and cup-to-disc ratio (P =.0064). In unaffected eyes, there were no correlations between peripapillary retinal VD and glaucoma-related parameters. Conclusions In acute PACG eyes, peripapillary retinal VD decreased significantly compared with the contralateral unaffected eyes. Peripapillary retinal VD was significantly correlated with other glaucomatous changes.",
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AB - Purpose To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle-closure glaucoma (PACG). Design Case-control study. Methods Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field (VF). Spectral-domain optical coherence tomography (SD-OCT) was used to obtain both structural OCT and OCT angiography (OCTA). Structural OCT scans provided thickness measurements of the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC). OCTA was used to measure all-plexus peripapillary retinal VD. Results In unaffected eyes, a dense microvascular network surrounded the disc on all-plexus retinal OCTA. The vascular network was visibly attenuated and focal capillary dropout was evident in acute PACG eyes. The peripapillary VD in acute PACG eyes was 66.6% ± 17.3% (mean ± standard deviation), which was significantly (P <.01) reduced compared to 87.2% ± 8.6% in the unaffected eyes. In acute PACG eyes, peripapillary retinal VD was positively correlated with RNFL and GCC thicknesses (P <.001 each) and negatively correlated with VF mean deviation (P =.002) and cup-to-disc ratio (P =.0064). In unaffected eyes, there were no correlations between peripapillary retinal VD and glaucoma-related parameters. Conclusions In acute PACG eyes, peripapillary retinal VD decreased significantly compared with the contralateral unaffected eyes. Peripapillary retinal VD was significantly correlated with other glaucomatous changes.

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