Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

Xiaogang Wang, Jia Yali, Rebecca Spain, Benjamin Potsaid, Jonathan J. Liu, Bernhard Baumann, Joachim Hornegger, James G. Fujimoto, Qiang Wu, David Huang

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Aims: To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).

Methods: Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.

Results: The mean ONH FI was 0.160±0.010 for the HC group, 0.156±0.017 for the MS-ON group, and 0.140±0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126±0.007, 0.127±0.010, and 0.129±0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.

Conclusions: Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.

Original languageEnglish (US)
Pages (from-to)1368-1373
Number of pages6
JournalBritish Journal of Ophthalmology
Volume98
Issue number10
DOIs
StatePublished - Oct 1 2014

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Optic Disk
Optical Coherence Tomography
Optic Neuritis
Multiple Sclerosis
Angiography
Perfusion

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. / Wang, Xiaogang; Yali, Jia; Spain, Rebecca; Potsaid, Benjamin; Liu, Jonathan J.; Baumann, Bernhard; Hornegger, Joachim; Fujimoto, James G.; Wu, Qiang; Huang, David.

In: British Journal of Ophthalmology, Vol. 98, No. 10, 01.10.2014, p. 1368-1373.

Research output: Contribution to journalArticle

Wang, Xiaogang ; Yali, Jia ; Spain, Rebecca ; Potsaid, Benjamin ; Liu, Jonathan J. ; Baumann, Bernhard ; Hornegger, Joachim ; Fujimoto, James G. ; Wu, Qiang ; Huang, David. / Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. In: British Journal of Ophthalmology. 2014 ; Vol. 98, No. 10. pp. 1368-1373.
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abstract = "Aims: To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).Methods: Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.Results: The mean ONH FI was 0.160±0.010 for the HC group, 0.156±0.017 for the MS-ON group, and 0.140±0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5{\%} compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43{\%} vs 5{\%}, p=0.01). Mean parafoveal FIs were 0.126±0.007, 0.127±0.010, and 0.129±0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03{\%} and 4.53{\%} for ONH FI, and 1.65{\%} and 3.55{\%} for parafoveal FI.Conclusions: Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.",
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T1 - Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

AU - Wang, Xiaogang

AU - Yali, Jia

AU - Spain, Rebecca

AU - Potsaid, Benjamin

AU - Liu, Jonathan J.

AU - Baumann, Bernhard

AU - Hornegger, Joachim

AU - Fujimoto, James G.

AU - Wu, Qiang

AU - Huang, David

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N2 - Aims: To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).Methods: Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.Results: The mean ONH FI was 0.160±0.010 for the HC group, 0.156±0.017 for the MS-ON group, and 0.140±0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126±0.007, 0.127±0.010, and 0.129±0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.Conclusions: Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.

AB - Aims: To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).Methods: Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.Results: The mean ONH FI was 0.160±0.010 for the HC group, 0.156±0.017 for the MS-ON group, and 0.140±0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126±0.007, 0.127±0.010, and 0.129±0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.Conclusions: Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.

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