Optical coherence tomography angiography features of diabetic retinopathy

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267 Scopus citations


Purpose: To describe the optical coherence tomography angiography features of diabetic retinopathy. Methods: Using a 70 kHz optical coherence tomography and the split-spectrum amplitude decorrelation angiography algorithm, 6 mm × 6 mm 3-dimensional angiograms of the macula of 4 patients with diabetic retinopathy were obtained and compared with fluorescein angiography for features cataloged by the Early Treatment of Diabetic Retinopathy Study. Results: Optical coherence tomography angiography detected enlargement and distortion of the foveal avascular zone, retinal capillary dropout, and pruning of arteriolar branches. Areas of capillary loss obscured by fluorescein leakage on fluorescein angiography were more clearly defined on optical coherence tomography angiography. Some areas of focal leakage on fluorescein angiography that were thought to be microaneurysms were found to be small tufts of neovascularization that extended above the inner limiting membrane. Conclusion: Optical coherence tomography angiography does not show leakage but can better delineate areas of capillary dropout and detect early retinal neovascularization. This new noninvasive angiography technology may be useful for routine surveillance of proliferative and ischemic changes in diabetic retinopathy.

Original languageEnglish (US)
Pages (from-to)2371-2376
Number of pages6
Issue number11
StatePublished - Oct 27 2015


  • Diabetic retinopathy
  • En face OCT
  • OCT angiography

ASJC Scopus subject areas

  • Ophthalmology


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