Optical coherence tomography

David Huang, Eric A. Swanson, Charles P. Lin, Joel S. Schuman, William G. Stinson, Warren Chang, Michael R. Hee, Thomas Flotte, Kenton Gregory, Carmen A. Puliafito, James G. Fujimoto

Research output: Contribution to journalArticle

10549 Scopus citations

Abstract

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as -10-10 of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

Original languageEnglish (US)
Pages (from-to)1178-1181
Number of pages4
JournalScience
Volume254
Issue number5035
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • General

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    Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K., Puliafito, C. A., & Fujimoto, J. G. (1991). Optical coherence tomography. Science, 254(5035), 1178-1181. https://doi.org/10.1126/science.1957169