Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, Owen McCarty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8091
DOIs
StatePublished - 2011
EventOptical Coherence Tomography and Coherence Techniques V - Munich, Germany
Duration: May 24 2011May 26 2011

Other

OtherOptical Coherence Tomography and Coherence Techniques V
CountryGermany
CityMunich
Period5/24/115/26/11

Fingerprint

glycolic acid
Optical tomography
Optical Coherence Tomography
Feasibility Studies
Nanoparticles
Coloring Agents
Dyes
Hot Temperature
tomography
dyes
Infrared imaging
Tissue
nanoparticles
acids
Acids
Molecular imaging
Sepharose
Contrast Media
Thermodynamic properties
Optical properties

Keywords

  • biomedical optical imaging
  • Contrast agents
  • image processing
  • Nanoparticles
  • Optical coherence tomography
  • optical interferometry
  • PLGA
  • spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography. / Subhash, Hrebesh M.; Xie, Hui; Smith, Jeffrey W.; McCarty, Owen.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8091 2011. 809108.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Xie, H, Smith, JW & McCarty, O 2011, Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8091, 809108, Optical Coherence Tomography and Coherence Techniques V, Munich, Germany, 5/24/11. https://doi.org/10.1117/12.889760
Subhash, Hrebesh M. ; Xie, Hui ; Smith, Jeffrey W. ; McCarty, Owen. / Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8091 2011.
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