Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, Owen McCarty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Techniques V
DOIs
StatePublished - Aug 1 2011
EventOptical Coherence Tomography and Coherence Techniques V - Munich, Germany
Duration: May 24 2011May 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8091
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Techniques V
CountryGermany
CityMunich
Period5/24/115/26/11

Keywords

  • Contrast agents
  • Nanoparticles
  • Optical coherence tomography
  • PLGA
  • biomedical optical imaging
  • image processing
  • optical interferometry
  • spectral interferometry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Subhash, H. M., Xie, H., Smith, J. W., & McCarty, O. (2011). Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography. In Optical Coherence Tomography and Coherence Techniques V [809108] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8091). https://doi.org/10.1117/12.889760