@inproceedings{f43bc02270de43e5aeca5765ced43412,
title = "Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography",
abstract = "Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.",
keywords = "Contrast agents, Nanoparticles, Optical coherence tomography, PLGA, biomedical optical imaging, image processing, optical interferometry, spectral interferometry",
author = "Subhash, {Hrebesh M.} and Hui Xie and Smith, {Jeffrey W.} and Owen McCarty",
year = "2011",
doi = "10.1117/12.889760",
language = "English (US)",
isbn = "9780819486882",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Coherence Tomography and Coherence Techniques V",
note = "Optical Coherence Tomography and Coherence Techniques V ; Conference date: 24-05-2011 Through 26-05-2011",
}