Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photothermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, Owen McCarty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

Original languageEnglish (US)
Title of host publicationOptics InfoBase Conference Papers
StatePublished - 2011
EventEuropean Conference on Biomedical Optics, ECBO 2011 - Munich, Germany
Duration: May 22 2011May 26 2011

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2011
CountryGermany
CityMunich
Period5/22/115/26/11

Fingerprint

Optical tomography
Dyes
tomography
dyes
Infrared imaging
Tissue
Nanoparticles
nanoparticles
acids
Acids
Molecular imaging
Thermodynamic properties
Optical properties
thermodynamic properties
Imaging techniques
optical properties
augmentation
Hot Temperature

Keywords

  • Biomedical optical imaging
  • Contrast agents
  • Image processing
  • Nanoparticles
  • Optical coherence tomography
  • Optical interferometry
  • PLGA
  • Spectral interferometry

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photothermal optical coherence tomography. / Subhash, Hrebesh M.; Xie, Hui; Smith, Jeffrey W.; McCarty, Owen.

Optics InfoBase Conference Papers. 2011. 809108.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Xie, H, Smith, JW & McCarty, O 2011, Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photothermal optical coherence tomography. in Optics InfoBase Conference Papers., 809108, European Conference on Biomedical Optics, ECBO 2011, Munich, Germany, 5/22/11.
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AU - McCarty, Owen

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AB - Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

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