@inproceedings{7df1417208dd4ef386ad333340c0ff92,
title = "Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photothermal optical coherence tomography",
abstract = "Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.",
keywords = "Biomedical optical imaging, Contrast agents, Image processing, Nanoparticles, Optical coherence tomography, Optical interferometry, PLGA, Spectral interferometry",
author = "Subhash, {Hrebesh M.} and Hui Xie and Smith, {Jeffrey W.} and Owen McCarty",
year = "2011",
doi = "10.1364/ecbo.2011.809108",
language = "English (US)",
isbn = "9780819486837",
series = "Optics InfoBase Conference Papers",
publisher = "Optical Society of America (OSA)",
booktitle = "European Conference on Biomedical Optics, ECBO 2011",
note = "European Conference on Biomedical Optics, ECBO 2011 ; Conference date: 22-05-2011 Through 26-05-2011",
}