Optical addressing of polymer beads in microdevices

Mihrimah Ozkan, Sangeeta Bhatia, Sadik Esener

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Integrated 'lab-on-a-chip' devices that utilize microfabrication tools are emerging for chemical and biological applications. Facile, robust sample manipulation within these devices will be particularly important for realizing the potential to perform many assays in parallel. Often, biomolecules are manipulated by derivatization to larger 'carrier beads'; therefore, we have developed a novel optical addressing scheme to localize polymer beads (0.8-10 μm in diameter) on an unpatterned semiconductor surface. This approach utilizes an optical microbeam that is directed on the substrate to create an active 'virtual' electrode. The localized charge is defined by the characteristics of the solid-liquid interface in the electrochemical system and serves to attract oppositely charged objects within the solution. Furthermore, to improve patterning efficiency and resolution, a photosensitive polymer coating is used on semiconductor substrates to minimize undesired effects of the dark current. Thus, illumination through a mask or use of multiple beams enables a nonlithographic, dynamic pattern transfer to a uniform substrate. In the future, this approach may be useful for 'off-chip', sterile manipulation of arrays of 'carrier beads' for high-throughput applications.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalSensors and Materials
Volume14
Issue number4
StatePublished - 2002
Externally publishedYes

Fingerprint

beads
Polymers
manipulators
polymers
Substrates
lab-on-a-chip devices
Semiconductor materials
Lab-on-a-chip
microbeams
Dark currents
Microfabrication
Biomolecules
liquid-solid interfaces
dark current
Masks
emerging
Assays
masks
Lighting
illumination

Keywords

  • μTAS
  • Biomems
  • Lab-on-a-chip
  • Microdevices
  • Optical addressing

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation

Cite this

Optical addressing of polymer beads in microdevices. / Ozkan, Mihrimah; Bhatia, Sangeeta; Esener, Sadik.

In: Sensors and Materials, Vol. 14, No. 4, 2002, p. 189-197.

Research output: Contribution to journalArticle

Ozkan, M, Bhatia, S & Esener, S 2002, 'Optical addressing of polymer beads in microdevices', Sensors and Materials, vol. 14, no. 4, pp. 189-197.
Ozkan, Mihrimah ; Bhatia, Sangeeta ; Esener, Sadik. / Optical addressing of polymer beads in microdevices. In: Sensors and Materials. 2002 ; Vol. 14, No. 4. pp. 189-197.
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