Optic neuropathy in chronic lymphocytic leukemia

Jon N. Currie, Simmons Lessell, Jayne S. Weiss, Daniel Albert, Irma M. Lessell, Elizabeth M. Benson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Ophthalmic and neurologic involvement in chronic lymphocytic leukemia is uncommon, and if it does occur, it is usually only late in the course of the disease. We report three cases in which progressive visual loss from optic nerve infiltration was an early clinical manifestation of chronic lymphocytic leukemia. Progressive optic atrophy with loss of acuity and visual field occurred in all cases, preceded in one patient by transient visual obscurations and disc edema. Surface marker studies of cerebrospinal fluid lymphocytes were useful in differentiating leukemic optic nerve infiltration from other causes of optic nerve damage. Optic nerve irradiation gave considerable clinical improvement in all three cases.

Original languageEnglish (US)
Pages (from-to)654-660
Number of pages7
JournalArchives of ophthalmology
Volume106
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Optic Nerve Diseases
B-Cell Chronic Lymphocytic Leukemia
Optic Nerve
Optic Atrophy
Visual Fields
Nervous System
Cerebrospinal Fluid
Edema
Lymphocytes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Currie, J. N., Lessell, S., Weiss, J. S., Albert, D., Lessell, I. M., & Benson, E. M. (1988). Optic neuropathy in chronic lymphocytic leukemia. Archives of ophthalmology, 106(5), 654-660. https://doi.org/10.1001/archopht.1988.01060130708030

Optic neuropathy in chronic lymphocytic leukemia. / Currie, Jon N.; Lessell, Simmons; Weiss, Jayne S.; Albert, Daniel; Lessell, Irma M.; Benson, Elizabeth M.

In: Archives of ophthalmology, Vol. 106, No. 5, 01.01.1988, p. 654-660.

Research output: Contribution to journalArticle

Currie, JN, Lessell, S, Weiss, JS, Albert, D, Lessell, IM & Benson, EM 1988, 'Optic neuropathy in chronic lymphocytic leukemia', Archives of ophthalmology, vol. 106, no. 5, pp. 654-660. https://doi.org/10.1001/archopht.1988.01060130708030
Currie, Jon N. ; Lessell, Simmons ; Weiss, Jayne S. ; Albert, Daniel ; Lessell, Irma M. ; Benson, Elizabeth M. / Optic neuropathy in chronic lymphocytic leukemia. In: Archives of ophthalmology. 1988 ; Vol. 106, No. 5. pp. 654-660.
@article{92505c219c1443f282fc4d6dc35ca6a3,
title = "Optic neuropathy in chronic lymphocytic leukemia",
abstract = "Ophthalmic and neurologic involvement in chronic lymphocytic leukemia is uncommon, and if it does occur, it is usually only late in the course of the disease. We report three cases in which progressive visual loss from optic nerve infiltration was an early clinical manifestation of chronic lymphocytic leukemia. Progressive optic atrophy with loss of acuity and visual field occurred in all cases, preceded in one patient by transient visual obscurations and disc edema. Surface marker studies of cerebrospinal fluid lymphocytes were useful in differentiating leukemic optic nerve infiltration from other causes of optic nerve damage. Optic nerve irradiation gave considerable clinical improvement in all three cases.",
author = "Currie, {Jon N.} and Simmons Lessell and Weiss, {Jayne S.} and Daniel Albert and Lessell, {Irma M.} and Benson, {Elizabeth M.}",
year = "1988",
month = "1",
day = "1",
doi = "10.1001/archopht.1988.01060130708030",
language = "English (US)",
volume = "106",
pages = "654--660",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Optic neuropathy in chronic lymphocytic leukemia

AU - Currie, Jon N.

AU - Lessell, Simmons

AU - Weiss, Jayne S.

AU - Albert, Daniel

AU - Lessell, Irma M.

AU - Benson, Elizabeth M.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Ophthalmic and neurologic involvement in chronic lymphocytic leukemia is uncommon, and if it does occur, it is usually only late in the course of the disease. We report three cases in which progressive visual loss from optic nerve infiltration was an early clinical manifestation of chronic lymphocytic leukemia. Progressive optic atrophy with loss of acuity and visual field occurred in all cases, preceded in one patient by transient visual obscurations and disc edema. Surface marker studies of cerebrospinal fluid lymphocytes were useful in differentiating leukemic optic nerve infiltration from other causes of optic nerve damage. Optic nerve irradiation gave considerable clinical improvement in all three cases.

AB - Ophthalmic and neurologic involvement in chronic lymphocytic leukemia is uncommon, and if it does occur, it is usually only late in the course of the disease. We report three cases in which progressive visual loss from optic nerve infiltration was an early clinical manifestation of chronic lymphocytic leukemia. Progressive optic atrophy with loss of acuity and visual field occurred in all cases, preceded in one patient by transient visual obscurations and disc edema. Surface marker studies of cerebrospinal fluid lymphocytes were useful in differentiating leukemic optic nerve infiltration from other causes of optic nerve damage. Optic nerve irradiation gave considerable clinical improvement in all three cases.

UR - http://www.scopus.com/inward/record.url?scp=0023941743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023941743&partnerID=8YFLogxK

U2 - 10.1001/archopht.1988.01060130708030

DO - 10.1001/archopht.1988.01060130708030

M3 - Article

C2 - 3358732

AN - SCOPUS:0023941743

VL - 106

SP - 654

EP - 660

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 5

ER -