Optic Nerve Head Extracellular Matrix in Primary Optic Atrophy and Experimental Glaucoma

John C. Morrison, Mary Ellen Dorman Pease, Gregory R. Dunkelberger, Harry A. Quigley

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Unilateral glaucomatous optic neuropathy and optic nerve transections were produced in cynomolgous monkeys, and the optic nerve heads were examined by light and electron microscopic immunohistochemistry. Glaucomatous nerve heads showed increased labeling for collagen type IV along the margins of beams in the lamina cribrosa, due to accumulation of basement membrane-like materials. We also noted material in the pores of the laminar beams that labeled with antibodies to collagen types I, III and IV, but not elastin. In transected eyes, increased type IV labeling of laminar beam margins resulted solely from redundant astrocyte basement membranes. Extracellular matrix deposition within laminar pores was not observed following optic nerve transection; hence this may be a selective response to elevated intraocular pressure. This response may alter the biochemical composition of the lamina cribrosa and its function in patients with elevated intraocular pressure.

Original languageEnglish (US)
Pages (from-to)1020-1024
Number of pages5
JournalArchives of ophthalmology
Volume108
Issue number7
DOIs
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Ophthalmology

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