Opportunities in multidimensional trace metal imaging

Taking copper-associated disease research to the next level

Stefan Vogt, Martina Ralle

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease and Menkes disease. Age-related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer disease. The role of copper in these diseases has been a topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized, and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with Alzheimer disease, for example, are still only poorly understood. To take metal-related disease research to the next level, emerging multidimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review describes how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field, specifically in Wilson disease and Alzheimer disease. It furthermore provides an overview of current developments and future applications in X-ray microscopic methods. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)1809-1820
Number of pages12
JournalAnalytical and Bioanalytical Chemistry
Volume405
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Copper
Metals
Imaging techniques
Research
Alzheimer Disease
Hepatolenticular Degeneration
Menkes Kinky Hair Syndrome
X-Rays
Biological Phenomena
Trace metals
X rays
Fluorescence microscopy
Fluorescent Dyes
Fluorescence Microscopy
Neurodegenerative Diseases
Oxidation-Reduction
Metabolism
Homeostasis
Proteins

Keywords

  • Copper
  • Fluorescence
  • Imaging
  • Neurological disease
  • X-ray

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

@article{d5107c06cc1a4de2b5f56998e2032d16,
title = "Opportunities in multidimensional trace metal imaging: Taking copper-associated disease research to the next level",
abstract = "Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease and Menkes disease. Age-related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer disease. The role of copper in these diseases has been a topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized, and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with Alzheimer disease, for example, are still only poorly understood. To take metal-related disease research to the next level, emerging multidimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review describes how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field, specifically in Wilson disease and Alzheimer disease. It furthermore provides an overview of current developments and future applications in X-ray microscopic methods. [Figure not available: see fulltext.]",
keywords = "Copper, Fluorescence, Imaging, Neurological disease, X-ray",
author = "Stefan Vogt and Martina Ralle",
year = "2013",
doi = "10.1007/s00216-012-6437-1",
language = "English (US)",
volume = "405",
pages = "1809--1820",
journal = "Fresenius Zeitschrift fur Analytische Chemie",
issn = "0016-1152",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Opportunities in multidimensional trace metal imaging

T2 - Taking copper-associated disease research to the next level

AU - Vogt, Stefan

AU - Ralle, Martina

PY - 2013

Y1 - 2013

N2 - Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease and Menkes disease. Age-related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer disease. The role of copper in these diseases has been a topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized, and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with Alzheimer disease, for example, are still only poorly understood. To take metal-related disease research to the next level, emerging multidimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review describes how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field, specifically in Wilson disease and Alzheimer disease. It furthermore provides an overview of current developments and future applications in X-ray microscopic methods. [Figure not available: see fulltext.]

AB - Copper plays an important role in numerous biological processes across all living systems predominantly because of its versatile redox behavior. Cellular copper homeostasis is tightly regulated and disturbances lead to severe disorders such as Wilson disease and Menkes disease. Age-related changes of copper metabolism have been implicated in other neurodegenerative disorders such as Alzheimer disease. The role of copper in these diseases has been a topic of mostly bioinorganic research efforts for more than a decade, metal-protein interactions have been characterized, and cellular copper pathways have been described. Despite these efforts, crucial aspects of how copper is associated with Alzheimer disease, for example, are still only poorly understood. To take metal-related disease research to the next level, emerging multidimensional imaging techniques are now revealing the copper metallome as the basis to better understand disease mechanisms. This review describes how recent advances in X-ray fluorescence microscopy and fluorescent copper probes have started to contribute to this field, specifically in Wilson disease and Alzheimer disease. It furthermore provides an overview of current developments and future applications in X-ray microscopic methods. [Figure not available: see fulltext.]

KW - Copper

KW - Fluorescence

KW - Imaging

KW - Neurological disease

KW - X-ray

UR - http://www.scopus.com/inward/record.url?scp=84873703551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873703551&partnerID=8YFLogxK

U2 - 10.1007/s00216-012-6437-1

DO - 10.1007/s00216-012-6437-1

M3 - Article

VL - 405

SP - 1809

EP - 1820

JO - Fresenius Zeitschrift fur Analytische Chemie

JF - Fresenius Zeitschrift fur Analytische Chemie

SN - 0016-1152

IS - 6

ER -