Opportunities and challenges in modeling human brain disorders in transgenic primates

Charles G. Jennings, Rogier Landman, Yang Zhou, Jitendra Sharma, Julia Hyman, J. Anthony Movshon, Zilong Qiu, Angela C. Roberts, Anna Roe, Xiaoqin Wang, Huihui Zhou, Liping Wang, Feng Zhang, Robert Desimone, Guoping Feng

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Molecular genetic tools have had a profound impact on neuroscience, but until recently their application has largely been confined to a few model species, most notably mouse, zebrafish, Drosophila melanogaster and Caenorhabditis elegans. With the development of new genome engineering technologies such as CRISPR, it is becoming increasingly feasible to apply these molecular tools in a wider range of species, including nonhuman primates. This will lead to many opportunities for brain research, but it will also pose challenges. Here we identify some of these opportunities and challenges in light of recent and foreseeable technological advances and offer some suggestions. Our main focus is on the creation of new primate disease models for understanding the pathological mechanisms of brain disorders and for developing new approaches to effective treatment. However, we also emphasize that primate genetic models have great potential to address many fundamental questions about brain function, providing an essential foundation for future progress in disease research.

Original languageEnglish (US)
Pages (from-to)1123-1130
Number of pages8
JournalNature Neuroscience
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

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Brain Diseases
Primates
Primate Diseases
Clustered Regularly Interspaced Short Palindromic Repeats
Genetic Models
Caenorhabditis elegans
Brain
Zebrafish
Neurosciences
Drosophila melanogaster
Research
Molecular Biology
Genome
Technology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Jennings, C. G., Landman, R., Zhou, Y., Sharma, J., Hyman, J., Movshon, J. A., ... Feng, G. (2016). Opportunities and challenges in modeling human brain disorders in transgenic primates. Nature Neuroscience, 19(9), 1123-1130. https://doi.org/10.1038/nn.4362

Opportunities and challenges in modeling human brain disorders in transgenic primates. / Jennings, Charles G.; Landman, Rogier; Zhou, Yang; Sharma, Jitendra; Hyman, Julia; Movshon, J. Anthony; Qiu, Zilong; Roberts, Angela C.; Roe, Anna; Wang, Xiaoqin; Zhou, Huihui; Wang, Liping; Zhang, Feng; Desimone, Robert; Feng, Guoping.

In: Nature Neuroscience, Vol. 19, No. 9, 01.09.2016, p. 1123-1130.

Research output: Contribution to journalReview article

Jennings, CG, Landman, R, Zhou, Y, Sharma, J, Hyman, J, Movshon, JA, Qiu, Z, Roberts, AC, Roe, A, Wang, X, Zhou, H, Wang, L, Zhang, F, Desimone, R & Feng, G 2016, 'Opportunities and challenges in modeling human brain disorders in transgenic primates', Nature Neuroscience, vol. 19, no. 9, pp. 1123-1130. https://doi.org/10.1038/nn.4362
Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA et al. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nature Neuroscience. 2016 Sep 1;19(9):1123-1130. https://doi.org/10.1038/nn.4362
Jennings, Charles G. ; Landman, Rogier ; Zhou, Yang ; Sharma, Jitendra ; Hyman, Julia ; Movshon, J. Anthony ; Qiu, Zilong ; Roberts, Angela C. ; Roe, Anna ; Wang, Xiaoqin ; Zhou, Huihui ; Wang, Liping ; Zhang, Feng ; Desimone, Robert ; Feng, Guoping. / Opportunities and challenges in modeling human brain disorders in transgenic primates. In: Nature Neuroscience. 2016 ; Vol. 19, No. 9. pp. 1123-1130.
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