Opioid signalling in the rat rostral ventrolateral medulla

Patrice G. Guyenet, Ruth L. Stornetta, Ann M. Schreihofer, Nicole M. Pelaez, Abdallah Hayar, Sue Aicher, Ida J. Llewellyn-Smith

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

1. The present article reviews several aspects of opioid signalling in the rostral ventrolateral medulla (RVLM) and their implications for the neural control of blood pressure. 2. In the RVLM, preproenkephalin (PPE) mRNA is expressed by bulbospinal cells that are strongly barosensitive. These putative presympathetic neurons includes C1 and non-C1 neurons. 3. In the RVLM, PPE mRNA is also present in GABAergic neurons that do not project to the thoracic spinal cord. 4. Rostral ventrolateral medulla presympathetic cells receive enkephalinergic inputs and express μ-opioid receptors (MOR). Some of their synaptic inputs also contain MOR. 5. Pre- and post-synaptic modulation of RVLM presympathetic neurons by MOR agonists has been demonstrated in slices of neonate brain. The post-synaptic effect is inhibitory (increased gK). Presynaptic effects include disfacilitation (reduction of glutamate release) and possibly dishinhibition (reduction of GABA release). 6. In conclusion, opioid signalling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure. Opioid peptides are made by the presympathetic, presumably excitatory, cells of the RVLM and by local GABAergic inhibitory neurons. In addition, RVLM presympathetic neurons are also controlled by opioid peptides at the pre- and post-synaptic level. μ-Opioid receptors are found post-synaptically, whereas presynaptic receptors probably include both μ and δ subtypes. Conditions that trigger the release of opioid peptides by presympathetic neurons or by inputs to these cells are not fully understood and may include decompensated haemorrhage and certain types of peripheral sensory stimulation related to acupuncture.

Original languageEnglish (US)
Pages (from-to)238-242
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume29
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Opioid Analgesics
Opioid Peptides
Neurons
GABAergic Neurons
Opioid Receptors
Presynaptic Receptors
Messenger RNA
Acupuncture
gamma-Aminobutyric Acid
Glutamic Acid
Spinal Cord
Arterial Pressure
Thorax
Hemorrhage
Blood Pressure
Brain
preproenkephalin

Keywords

  • Bulbospinal neurons
  • Enkephalins
  • Neural control of blood pressure
  • Opioid peptides
  • Presympathetic neurons
  • Sympathetic system

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Guyenet, P. G., Stornetta, R. L., Schreihofer, A. M., Pelaez, N. M., Hayar, A., Aicher, S., & Llewellyn-Smith, I. J. (2002). Opioid signalling in the rat rostral ventrolateral medulla. Clinical and Experimental Pharmacology and Physiology, 29(3), 238-242. https://doi.org/10.1046/j.1440-1681.2002.03636.x

Opioid signalling in the rat rostral ventrolateral medulla. / Guyenet, Patrice G.; Stornetta, Ruth L.; Schreihofer, Ann M.; Pelaez, Nicole M.; Hayar, Abdallah; Aicher, Sue; Llewellyn-Smith, Ida J.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 29, No. 3, 2002, p. 238-242.

Research output: Contribution to journalArticle

Guyenet, PG, Stornetta, RL, Schreihofer, AM, Pelaez, NM, Hayar, A, Aicher, S & Llewellyn-Smith, IJ 2002, 'Opioid signalling in the rat rostral ventrolateral medulla', Clinical and Experimental Pharmacology and Physiology, vol. 29, no. 3, pp. 238-242. https://doi.org/10.1046/j.1440-1681.2002.03636.x
Guyenet, Patrice G. ; Stornetta, Ruth L. ; Schreihofer, Ann M. ; Pelaez, Nicole M. ; Hayar, Abdallah ; Aicher, Sue ; Llewellyn-Smith, Ida J. / Opioid signalling in the rat rostral ventrolateral medulla. In: Clinical and Experimental Pharmacology and Physiology. 2002 ; Vol. 29, No. 3. pp. 238-242.
@article{127cb15a79154cdb83844d182a11e0f1,
title = "Opioid signalling in the rat rostral ventrolateral medulla",
abstract = "1. The present article reviews several aspects of opioid signalling in the rostral ventrolateral medulla (RVLM) and their implications for the neural control of blood pressure. 2. In the RVLM, preproenkephalin (PPE) mRNA is expressed by bulbospinal cells that are strongly barosensitive. These putative presympathetic neurons includes C1 and non-C1 neurons. 3. In the RVLM, PPE mRNA is also present in GABAergic neurons that do not project to the thoracic spinal cord. 4. Rostral ventrolateral medulla presympathetic cells receive enkephalinergic inputs and express μ-opioid receptors (MOR). Some of their synaptic inputs also contain MOR. 5. Pre- and post-synaptic modulation of RVLM presympathetic neurons by MOR agonists has been demonstrated in slices of neonate brain. The post-synaptic effect is inhibitory (increased gK). Presynaptic effects include disfacilitation (reduction of glutamate release) and possibly dishinhibition (reduction of GABA release). 6. In conclusion, opioid signalling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure. Opioid peptides are made by the presympathetic, presumably excitatory, cells of the RVLM and by local GABAergic inhibitory neurons. In addition, RVLM presympathetic neurons are also controlled by opioid peptides at the pre- and post-synaptic level. μ-Opioid receptors are found post-synaptically, whereas presynaptic receptors probably include both μ and δ subtypes. Conditions that trigger the release of opioid peptides by presympathetic neurons or by inputs to these cells are not fully understood and may include decompensated haemorrhage and certain types of peripheral sensory stimulation related to acupuncture.",
keywords = "Bulbospinal neurons, Enkephalins, Neural control of blood pressure, Opioid peptides, Presympathetic neurons, Sympathetic system",
author = "Guyenet, {Patrice G.} and Stornetta, {Ruth L.} and Schreihofer, {Ann M.} and Pelaez, {Nicole M.} and Abdallah Hayar and Sue Aicher and Llewellyn-Smith, {Ida J.}",
year = "2002",
doi = "10.1046/j.1440-1681.2002.03636.x",
language = "English (US)",
volume = "29",
pages = "238--242",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Opioid signalling in the rat rostral ventrolateral medulla

AU - Guyenet, Patrice G.

AU - Stornetta, Ruth L.

AU - Schreihofer, Ann M.

AU - Pelaez, Nicole M.

AU - Hayar, Abdallah

AU - Aicher, Sue

AU - Llewellyn-Smith, Ida J.

PY - 2002

Y1 - 2002

N2 - 1. The present article reviews several aspects of opioid signalling in the rostral ventrolateral medulla (RVLM) and their implications for the neural control of blood pressure. 2. In the RVLM, preproenkephalin (PPE) mRNA is expressed by bulbospinal cells that are strongly barosensitive. These putative presympathetic neurons includes C1 and non-C1 neurons. 3. In the RVLM, PPE mRNA is also present in GABAergic neurons that do not project to the thoracic spinal cord. 4. Rostral ventrolateral medulla presympathetic cells receive enkephalinergic inputs and express μ-opioid receptors (MOR). Some of their synaptic inputs also contain MOR. 5. Pre- and post-synaptic modulation of RVLM presympathetic neurons by MOR agonists has been demonstrated in slices of neonate brain. The post-synaptic effect is inhibitory (increased gK). Presynaptic effects include disfacilitation (reduction of glutamate release) and possibly dishinhibition (reduction of GABA release). 6. In conclusion, opioid signalling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure. Opioid peptides are made by the presympathetic, presumably excitatory, cells of the RVLM and by local GABAergic inhibitory neurons. In addition, RVLM presympathetic neurons are also controlled by opioid peptides at the pre- and post-synaptic level. μ-Opioid receptors are found post-synaptically, whereas presynaptic receptors probably include both μ and δ subtypes. Conditions that trigger the release of opioid peptides by presympathetic neurons or by inputs to these cells are not fully understood and may include decompensated haemorrhage and certain types of peripheral sensory stimulation related to acupuncture.

AB - 1. The present article reviews several aspects of opioid signalling in the rostral ventrolateral medulla (RVLM) and their implications for the neural control of blood pressure. 2. In the RVLM, preproenkephalin (PPE) mRNA is expressed by bulbospinal cells that are strongly barosensitive. These putative presympathetic neurons includes C1 and non-C1 neurons. 3. In the RVLM, PPE mRNA is also present in GABAergic neurons that do not project to the thoracic spinal cord. 4. Rostral ventrolateral medulla presympathetic cells receive enkephalinergic inputs and express μ-opioid receptors (MOR). Some of their synaptic inputs also contain MOR. 5. Pre- and post-synaptic modulation of RVLM presympathetic neurons by MOR agonists has been demonstrated in slices of neonate brain. The post-synaptic effect is inhibitory (increased gK). Presynaptic effects include disfacilitation (reduction of glutamate release) and possibly dishinhibition (reduction of GABA release). 6. In conclusion, opioid signalling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure. Opioid peptides are made by the presympathetic, presumably excitatory, cells of the RVLM and by local GABAergic inhibitory neurons. In addition, RVLM presympathetic neurons are also controlled by opioid peptides at the pre- and post-synaptic level. μ-Opioid receptors are found post-synaptically, whereas presynaptic receptors probably include both μ and δ subtypes. Conditions that trigger the release of opioid peptides by presympathetic neurons or by inputs to these cells are not fully understood and may include decompensated haemorrhage and certain types of peripheral sensory stimulation related to acupuncture.

KW - Bulbospinal neurons

KW - Enkephalins

KW - Neural control of blood pressure

KW - Opioid peptides

KW - Presympathetic neurons

KW - Sympathetic system

UR - http://www.scopus.com/inward/record.url?scp=0036126475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036126475&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1681.2002.03636.x

DO - 10.1046/j.1440-1681.2002.03636.x

M3 - Article

VL - 29

SP - 238

EP - 242

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 3

ER -