Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

G. K. Aghajanian, J. H. Kogan, B. Moghaddam

Research output: Contribution to journalArticle

183 Scopus citations

Abstract

Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
JournalBrain research
Volume636
Issue number1
DOIs
StatePublished - Feb 4 1994

Keywords

  • Aspartate
  • Excitatory amino acid
  • Glutamate
  • Locus coeruleus
  • Microdialysis
  • Naltrexone
  • Opiate withdrawal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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