Opiate modulating properties of nociceptin/orphanin FQ

Laura M. Harrison, David Grandy

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Abstract

    The recently discovered peptide nociceptin/orphanin FQ (N/OFQ) and its receptor NOR share many structural similarities with the opioid peptides and their receptors. The anatomical distributions of N/OFQ and NOR are similar to those of opioid peptides and receptors. In addition, NOR and opiate receptors couple via the same G-proteins to similar effectors, such as Ca2+ channels, K+ channels, adenylyl cyclase, and several protein kinases. Thus, the behavioral effects of N/OFQ have been investigated in the context of known opiate effects, and a possible connection has been sought between the effects of these two homologous signaling systems. Originally characterized as a nociception-producing peptide, N/OFQ has now been shown to have diverse effects on nociception, as well as effects on many other behaviors. With regard to nociception, the peptide has been reported to produce hyperalgesia, reversal of opioid-mediated analgesia, analgesia, and allodynia. N/OFQ also has effects on other behaviors, such as locomotion, feeding, anxiety, spatial attention, reproductive behaviors, and opiate tolerance. The relationship between opiates and N/OFQ is strengthened by the fact that opiates also affect these behaviors. However, the exact nature of the relationship of N/OFQ with opiates - opiate-like versus antiopiate - remains controversial. This review will detail the diverse effects of N/OFQ and suggest that this peptide, like other putative antiopiate peptides, can be described as 'opiate modulating.' (C) 2000 Elsevier Science Inc.

    Original languageEnglish (US)
    Pages (from-to)151-172
    Number of pages22
    JournalPeptides
    Volume21
    Issue number1
    DOIs
    StatePublished - Jan 2000

    Fingerprint

    Opiate Alkaloids
    Nociception
    Peptides
    Peptide Receptors
    Opioid Peptides
    Hyperalgesia
    Opioid Receptors
    Analgesia
    Reproductive Behavior
    nociceptin
    Locomotion
    GTP-Binding Proteins
    Adenylyl Cyclases
    Protein Kinases
    Opioid Analgesics
    Anxiety

    Keywords

    • Antiopiate
    • Neuropeptide FF
    • Nociceptin
    • Orphanin FQ
    • Tyr-MIF-1

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Physiology
    • Cellular and Molecular Neuroscience

    Cite this

    Opiate modulating properties of nociceptin/orphanin FQ. / Harrison, Laura M.; Grandy, David.

    In: Peptides, Vol. 21, No. 1, 01.2000, p. 151-172.

    Research output: Contribution to journalArticle

    Harrison, Laura M. ; Grandy, David. / Opiate modulating properties of nociceptin/orphanin FQ. In: Peptides. 2000 ; Vol. 21, No. 1. pp. 151-172.
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