Ophthalmologic and systemic manifestations of Alström's disease

Robert H. Millay, Richard Weleber, John R. Heckenlively

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Alström's syndrome consists of pigmentary retinopathy, diabetes, obesity, normal mental capacity, and sensorineural deafness. The early retinal findings are optic atrophy, salt-and-pepper pigment epithelial abnormalities, and marked vascular attenuation. Later in the disease process, diffuse areas of chorioretinal atrophy and large clumps of pigment develop. Severe visual loss in the first decade is characteristic and is an important point in the differential diagnosis. Clinically evident renal disease is a variable age-related phenomenon, and is probably the most frequent cause of death.

Original languageEnglish (US)
Pages (from-to)482-490
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume102
Issue number4
StatePublished - Oct 15 1986

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Optic Atrophy
Retinitis Pigmentosa
Deafness
Atrophy
Blood Vessels
Cause of Death
Differential Diagnosis
Obesity
Salts
Kidney

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ophthalmologic and systemic manifestations of Alström's disease. / Millay, Robert H.; Weleber, Richard; Heckenlively, John R.

In: American Journal of Ophthalmology, Vol. 102, No. 4, 15.10.1986, p. 482-490.

Research output: Contribution to journalArticle

Millay, Robert H. ; Weleber, Richard ; Heckenlively, John R. / Ophthalmologic and systemic manifestations of Alström's disease. In: American Journal of Ophthalmology. 1986 ; Vol. 102, No. 4. pp. 482-490.
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