Ophthalmologic and systemic manifestations of Alström's disease

Robert H. Millay, Richard G. Weleber, John R. Heckenlively

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Alström's syndrome consists of pigmentary retinopathy, diabetes, obesity, normal mental capacity, and sensorineural deafness. The early retinal findings are optic atrophy, salt-and-pepper pigment epithelial abnormalities, and marked vascular attenuation. Later in the disease process, diffuse areas of chorioretinal atrophy and large clumps of pigment develop. Severe visual loss in the first decade is characteristic and is an important point in the differential diagnosis. Clinically evident renal disease is a variable age-related phenomenon, and is probably the most frequent cause of death.

Original languageEnglish (US)
Pages (from-to)482-490
Number of pages9
JournalAmerican journal of ophthalmology
Volume102
Issue number4
DOIs
StatePublished - Oct 15 1986

ASJC Scopus subject areas

  • Ophthalmology

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