Ophthalmic diagnostics using optical coherence tomography

Joseph A. Izatt, Michael R. Hee, David Huang, James G. Fujimoto, Eric A. Swanson, Charles P. Lin, Joel S. Shuman, Carmen A. Puliafito

Research output: Contribution to journalConference article

29 Citations (Scopus)

Abstract

We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (< 20 μm) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1877
DOIs
StatePublished - Jun 24 1993
EventOphthalmic Technologies III 1993 - Los Angeles, United States
Duration: Jan 17 1993Jan 22 1993

Fingerprint

Optical Coherence Tomography
Optical tomography
Diagnostics
tomography
Iris
Non-contact
Imaging techniques
High Resolution
Imaging
glaucoma
Cornea
cataracts
Angle
Optical Imaging
cornea
high resolution
image resolution
pathology
Pathology
Dynamic Range

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Izatt, J. A., Hee, M. R., Huang, D., Fujimoto, J. G., Swanson, E. A., Lin, C. P., ... Puliafito, C. A. (1993). Ophthalmic diagnostics using optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering, 1877, 136-144. https://doi.org/10.1117/12.147520

Ophthalmic diagnostics using optical coherence tomography. / Izatt, Joseph A.; Hee, Michael R.; Huang, David; Fujimoto, James G.; Swanson, Eric A.; Lin, Charles P.; Shuman, Joel S.; Puliafito, Carmen A.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 1877, 24.06.1993, p. 136-144.

Research output: Contribution to journalConference article

Izatt, JA, Hee, MR, Huang, D, Fujimoto, JG, Swanson, EA, Lin, CP, Shuman, JS & Puliafito, CA 1993, 'Ophthalmic diagnostics using optical coherence tomography', Proceedings of SPIE - The International Society for Optical Engineering, vol. 1877, pp. 136-144. https://doi.org/10.1117/12.147520
Izatt, Joseph A. ; Hee, Michael R. ; Huang, David ; Fujimoto, James G. ; Swanson, Eric A. ; Lin, Charles P. ; Shuman, Joel S. ; Puliafito, Carmen A. / Ophthalmic diagnostics using optical coherence tomography. In: Proceedings of SPIE - The International Society for Optical Engineering. 1993 ; Vol. 1877. pp. 136-144.
@article{b6cc4e178d79478e93a29a27901e7eb5,
title = "Ophthalmic diagnostics using optical coherence tomography",
abstract = "We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (< 20 μm) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.",
author = "Izatt, {Joseph A.} and Hee, {Michael R.} and David Huang and Fujimoto, {James G.} and Swanson, {Eric A.} and Lin, {Charles P.} and Shuman, {Joel S.} and Puliafito, {Carmen A.}",
year = "1993",
month = "6",
day = "24",
doi = "10.1117/12.147520",
language = "English (US)",
volume = "1877",
pages = "136--144",
journal = "Proceedings of SPIE - The International Society for Optical Engineering",
issn = "0277-786X",
publisher = "SPIE",

}

TY - JOUR

T1 - Ophthalmic diagnostics using optical coherence tomography

AU - Izatt, Joseph A.

AU - Hee, Michael R.

AU - Huang, David

AU - Fujimoto, James G.

AU - Swanson, Eric A.

AU - Lin, Charles P.

AU - Shuman, Joel S.

AU - Puliafito, Carmen A.

PY - 1993/6/24

Y1 - 1993/6/24

N2 - We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (< 20 μm) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.

AB - We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (< 20 μm) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.

UR - http://www.scopus.com/inward/record.url?scp=85076203023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076203023&partnerID=8YFLogxK

U2 - 10.1117/12.147520

DO - 10.1117/12.147520

M3 - Conference article

AN - SCOPUS:85076203023

VL - 1877

SP - 136

EP - 144

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

SN - 0277-786X

ER -