Operational definitions of asthma in studies on its aetiology

Juha Pekkanen, J. Sunyer, J. M. Anto, P. Burney, M. Abramson, J. Kutin, P. Vermeire, F. van Bastelaer, J. Bousquet, F. Neukirch, R. Liard, I. Pin, C. Pison, A. Taytard, H. Magnussen, D. Nowak, H. E. Wichmann, J. Heinrich, T. Gislason, D. GislasonJ. Prichard, S. Allwright, D. MacLeod, M. Bugiani, C. Bucca, C. Romano, R. de Marco, V. Lo Cascio, C. Campello, A. Marinoni, I. Cerveri, L. Casali, B. Rijcken, A. Kremer, J. Crane, S. Lewis, A. Gulsvik, E. Omenaas, J. Soriano, A. Tobías, J. Roca, M. Kogevinas, N. Muniozguren, J. Ramos González, A. Capelastegui, J. Martinez-Moratalla, E. Almar, J. Maldonado, A. Pereira, J. Sánchez, F. Payo, I. Huerta, G. Boman, C. Janson, E. Bjornsson, L. Rosenhall, E. Norrman, B. Lundback, N. Lindholm, P. Plaschke, U. Ackermann-Liebrich, N. Künzli, A. Perruchoud, M. Burr, J. Layzqll, R. Hall, B. Harrison, J. Stark, S. Chinn, C. Luczynska, D. Jarvis, E. Lai, A (Sonia) Buist, W. Vollmer, Molly Osborne

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The most popular way to define asthma based on questionnaires is to use definitions taken from cross-sectional international studies on asthma. These definitions may not, however, be optimal for future studies focusing on risk factors of asthma. The current authors, therefore, compared the performance of different operational definitions of asthma. The European Community Respiratory Health Study I was a cross-sectional study of 21,924 subjects aged between 25-44 yrs in 18 countries. Operational definitions of asthma compared included different combinations of symptoms of asthma and bronchial hyperresponsiveness. A continuous asthma score, ranging from 0-8, was defined as the sum of positive answers to eight main symptom questions. There was no threshold in the associations of asthma symptoms with severity or risk factors of asthma, which would have suggested a dichotomous definition of asthma. Using dichotomous definitions requiring the presence of several asthma symptoms strengthened associations with studied risk factors, and also increased the estimated specificity and positive predictive value. Using a continuous asthma score also improved the power of the analyses. In conclusion, dichotomous definitions of asthma yielding higher odds ratios are achieved by requiring positive responses to several questions on symptoms. However, symptoms of asthma are possibly best analysed as a continuous asthma score.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalEuropean Respiratory Journal
Volume26
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Asthma
Cross-Sectional Studies
European Union
Odds Ratio

Keywords

  • Asthma
  • Definition
  • Epidemiology
  • Methods
  • Risk factor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Pekkanen, J., Sunyer, J., Anto, J. M., Burney, P., Abramson, M., Kutin, J., ... Osborne, M. (2005). Operational definitions of asthma in studies on its aetiology. European Respiratory Journal, 26(1), 28-35. https://doi.org/10.1183/09031936.05.00120104

Operational definitions of asthma in studies on its aetiology. / Pekkanen, Juha; Sunyer, J.; Anto, J. M.; Burney, P.; Abramson, M.; Kutin, J.; Vermeire, P.; van Bastelaer, F.; Bousquet, J.; Neukirch, F.; Liard, R.; Pin, I.; Pison, C.; Taytard, A.; Magnussen, H.; Nowak, D.; Wichmann, H. E.; Heinrich, J.; Gislason, T.; Gislason, D.; Prichard, J.; Allwright, S.; MacLeod, D.; Bugiani, M.; Bucca, C.; Romano, C.; de Marco, R.; Lo Cascio, V.; Campello, C.; Marinoni, A.; Cerveri, I.; Casali, L.; Rijcken, B.; Kremer, A.; Crane, J.; Lewis, S.; Gulsvik, A.; Omenaas, E.; Soriano, J.; Tobías, A.; Roca, J.; Kogevinas, M.; Muniozguren, N.; Ramos González, J.; Capelastegui, A.; Martinez-Moratalla, J.; Almar, E.; Maldonado, J.; Pereira, A.; Sánchez, J.; Payo, F.; Huerta, I.; Boman, G.; Janson, C.; Bjornsson, E.; Rosenhall, L.; Norrman, E.; Lundback, B.; Lindholm, N.; Plaschke, P.; Ackermann-Liebrich, U.; Künzli, N.; Perruchoud, A.; Burr, M.; Layzqll, J.; Hall, R.; Harrison, B.; Stark, J.; Chinn, S.; Luczynska, C.; Jarvis, D.; Lai, E.; Buist, A (Sonia); Vollmer, W.; Osborne, Molly.

In: European Respiratory Journal, Vol. 26, No. 1, 07.2005, p. 28-35.

Research output: Contribution to journalArticle

Pekkanen, J, Sunyer, J, Anto, JM, Burney, P, Abramson, M, Kutin, J, Vermeire, P, van Bastelaer, F, Bousquet, J, Neukirch, F, Liard, R, Pin, I, Pison, C, Taytard, A, Magnussen, H, Nowak, D, Wichmann, HE, Heinrich, J, Gislason, T, Gislason, D, Prichard, J, Allwright, S, MacLeod, D, Bugiani, M, Bucca, C, Romano, C, de Marco, R, Lo Cascio, V, Campello, C, Marinoni, A, Cerveri, I, Casali, L, Rijcken, B, Kremer, A, Crane, J, Lewis, S, Gulsvik, A, Omenaas, E, Soriano, J, Tobías, A, Roca, J, Kogevinas, M, Muniozguren, N, Ramos González, J, Capelastegui, A, Martinez-Moratalla, J, Almar, E, Maldonado, J, Pereira, A, Sánchez, J, Payo, F, Huerta, I, Boman, G, Janson, C, Bjornsson, E, Rosenhall, L, Norrman, E, Lundback, B, Lindholm, N, Plaschke, P, Ackermann-Liebrich, U, Künzli, N, Perruchoud, A, Burr, M, Layzqll, J, Hall, R, Harrison, B, Stark, J, Chinn, S, Luczynska, C, Jarvis, D, Lai, E, Buist, AS, Vollmer, W & Osborne, M 2005, 'Operational definitions of asthma in studies on its aetiology', European Respiratory Journal, vol. 26, no. 1, pp. 28-35. https://doi.org/10.1183/09031936.05.00120104
Pekkanen J, Sunyer J, Anto JM, Burney P, Abramson M, Kutin J et al. Operational definitions of asthma in studies on its aetiology. European Respiratory Journal. 2005 Jul;26(1):28-35. https://doi.org/10.1183/09031936.05.00120104
Pekkanen, Juha ; Sunyer, J. ; Anto, J. M. ; Burney, P. ; Abramson, M. ; Kutin, J. ; Vermeire, P. ; van Bastelaer, F. ; Bousquet, J. ; Neukirch, F. ; Liard, R. ; Pin, I. ; Pison, C. ; Taytard, A. ; Magnussen, H. ; Nowak, D. ; Wichmann, H. E. ; Heinrich, J. ; Gislason, T. ; Gislason, D. ; Prichard, J. ; Allwright, S. ; MacLeod, D. ; Bugiani, M. ; Bucca, C. ; Romano, C. ; de Marco, R. ; Lo Cascio, V. ; Campello, C. ; Marinoni, A. ; Cerveri, I. ; Casali, L. ; Rijcken, B. ; Kremer, A. ; Crane, J. ; Lewis, S. ; Gulsvik, A. ; Omenaas, E. ; Soriano, J. ; Tobías, A. ; Roca, J. ; Kogevinas, M. ; Muniozguren, N. ; Ramos González, J. ; Capelastegui, A. ; Martinez-Moratalla, J. ; Almar, E. ; Maldonado, J. ; Pereira, A. ; Sánchez, J. ; Payo, F. ; Huerta, I. ; Boman, G. ; Janson, C. ; Bjornsson, E. ; Rosenhall, L. ; Norrman, E. ; Lundback, B. ; Lindholm, N. ; Plaschke, P. ; Ackermann-Liebrich, U. ; Künzli, N. ; Perruchoud, A. ; Burr, M. ; Layzqll, J. ; Hall, R. ; Harrison, B. ; Stark, J. ; Chinn, S. ; Luczynska, C. ; Jarvis, D. ; Lai, E. ; Buist, A (Sonia) ; Vollmer, W. ; Osborne, Molly. / Operational definitions of asthma in studies on its aetiology. In: European Respiratory Journal. 2005 ; Vol. 26, No. 1. pp. 28-35.
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