Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice

Robin D. Wood, Elaine H. Shen, Julia A. Chester, Tamara J. Phillips

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The replicate lines of selectively bred FAST and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH). FAST mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of FAST and SLOW mice to EtOH during development. We assessed the locomotor responses of FAST and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing FAST mice exhibited ethanol stimulation by P15 (replicate 1) or P30 (replicate 2). At these ages, responses of FAST mice differed from those of SLOW. The stimulant response in FAST mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by P15. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume62
Issue number2
DOIs
StatePublished - Feb 1 1999

Keywords

  • Development
  • Ethanol
  • FAST and SLOW mice
  • Hypothermia
  • Locomotor activity
  • Ontogeny
  • Pharmacogenetics
  • Selected mouse lines

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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