Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus

Wei Shi, Anjin Xianyu, Zhi Han, Xing Tang, Zhizhong Li, Haining Zhong, Tianyi Mao, Kun Huang, Song Hai Shi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The thalamus connects the cortex with other brain regions and supports sensory perception, movement, and cognitive function via numerous distinct nuclei. However, the mechanisms underlying the development and organization of diverse thalamic nuclei remain largely unknown. Here we report an intricate ontogenetic logic of mouse thalamic structures. Individual radial glial progenitors in the developing thalamus actively divide and produce a cohort of neuronal progeny that shows striking spatial configuration and nuclear occupation related to functionality. Whereas the anterior clonal cluster displays relatively more tangential dispersion and contributes predominantly to nuclei with cognitive functions, the medial ventral posterior clonal cluster forms prominent radial arrays and contributes mostly to nuclei with sensory- or motor-related activities. Moreover, the first-order and higher-order sensory and motor nuclei across different modalities are largely segregated clonally. Notably, sonic hedgehog signaling activity influences clonal spatial distribution. Our study reveals lineage relationship to be a critical regulator of nonlaminated thalamus development and organization.

Original languageEnglish (US)
Pages (from-to)516-528
Number of pages13
JournalNature Neuroscience
Volume20
Issue number4
DOIs
StatePublished - Mar 29 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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