On–Off Phenomenon in Parkinson's Disease

G. Gopinathan; A. N. Lieberman; A. Neophytides; M. Goldstein; J. G. de Yebenes; M. A. Mena; V. Muradas; E. Bazan; J. Reiriz; John G. Nutt; William R. Woodward; John P. Hammerstad; Julie H. Carter; John L. Anderson

doi:10.1056/NEJM198407193110316

On–Off Phenomenon in Parkinson's Disease

G. Gopinathan, A. N. Lieberman, A. Neophytides, M. Goldstein, J. G. de Yebenes, M. A. Mena, V. Muradas, E. Bazan, J. Reiriz, John G. Nutt, William R. Woodward, John P. Hammerstad, Julie H. Carter, John L. Anderson

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: We congratulate Nutt et al. for their study of the effect of diet and amino acids on the on–off phenomenon of Parkinson's disease (Feb. 23 issue).¹ Their observations confirm our own experience in a limited study using oral levodopa and decarboxylase inhibitors.² One important aspect of the on–off phenomenon in patients with Parkinson's disease treated with levodopa is that, with rare exceptions, it does not appear early in the treatment course. If protein in the food interfering with the transport or uptake of dopamine were a key factor in the genesis of the phenomenon, one would expect.

Original language	English (US)
Pages (from-to)	192-194
Number of pages	3
Journal	New England Journal of Medicine
Volume	311
Issue number	3
DOIs	https://doi.org/10.1056/NEJM198407193110316
State	Published - Jul 19 1984

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1056/NEJM198407193110316

Cite this

@article{da0289061d6049d8960f7b6d7ddae113,

title = "On–Off Phenomenon in Parkinson's Disease",

abstract = "To the Editor: We congratulate Nutt et al. for their study of the effect of diet and amino acids on the on–off phenomenon of Parkinson's disease (Feb. 23 issue).1 Their observations confirm our own experience in a limited study using oral levodopa and decarboxylase inhibitors.2 One important aspect of the on–off phenomenon in patients with Parkinson's disease treated with levodopa is that, with rare exceptions, it does not appear early in the treatment course. If protein in the food interfering with the transport or uptake of dopamine were a key factor in the genesis of the phenomenon, one would expect.",

author = "G. Gopinathan and Lieberman, {A. N.} and A. Neophytides and M. Goldstein and {de Yebenes}, {J. G.} and Mena, {M. A.} and V. Muradas and E. Bazan and J. Reiriz and Nutt, {John G.} and Woodward, {William R.} and Hammerstad, {John P.} and Carter, {Julie H.} and Anderson, {John L.}",

year = "1984",

month = jul,

day = "19",

doi = "10.1056/NEJM198407193110316",

language = "English (US)",

volume = "311",

pages = "192--194",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "3",

}

TY - JOUR

T1 - On–Off Phenomenon in Parkinson's Disease

AU - Gopinathan, G.

AU - Lieberman, A. N.

AU - Neophytides, A.

AU - Goldstein, M.

AU - de Yebenes, J. G.

AU - Mena, M. A.

AU - Muradas, V.

AU - Bazan, E.

AU - Reiriz, J.

AU - Nutt, John G.

AU - Woodward, William R.

AU - Hammerstad, John P.

AU - Carter, Julie H.

AU - Anderson, John L.

PY - 1984/7/19

Y1 - 1984/7/19

N2 - To the Editor: We congratulate Nutt et al. for their study of the effect of diet and amino acids on the on–off phenomenon of Parkinson's disease (Feb. 23 issue).1 Their observations confirm our own experience in a limited study using oral levodopa and decarboxylase inhibitors.2 One important aspect of the on–off phenomenon in patients with Parkinson's disease treated with levodopa is that, with rare exceptions, it does not appear early in the treatment course. If protein in the food interfering with the transport or uptake of dopamine were a key factor in the genesis of the phenomenon, one would expect.

AB - To the Editor: We congratulate Nutt et al. for their study of the effect of diet and amino acids on the on–off phenomenon of Parkinson's disease (Feb. 23 issue).1 Their observations confirm our own experience in a limited study using oral levodopa and decarboxylase inhibitors.2 One important aspect of the on–off phenomenon in patients with Parkinson's disease treated with levodopa is that, with rare exceptions, it does not appear early in the treatment course. If protein in the food interfering with the transport or uptake of dopamine were a key factor in the genesis of the phenomenon, one would expect.

UR - http://www.scopus.com/inward/record.url?scp=0021239253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021239253&partnerID=8YFLogxK

U2 - 10.1056/NEJM198407193110316

DO - 10.1056/NEJM198407193110316

M3 - Letter

C2 - 6738606

AN - SCOPUS:0021239253

SN - 0028-4793

VL - 311

SP - 192

EP - 194

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 3

ER -

On–Off Phenomenon in Parkinson's Disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this