On–Off Phenomenon in Parkinson's Disease

G. Gopinathan, A. N. Lieberman, A. Neophytides, M. Goldstein, J. G. de Yebenes, M. A. Mena, V. Muradas, E. Bazan, J. Reiriz, John G. Nutt, William R. Woodward, John P. Hammerstad, Julie H. Carter, John L. Anderson

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: We congratulate Nutt et al. for their study of the effect of diet and amino acids on the on–off phenomenon of Parkinson's disease (Feb. 23 issue).1 Their observations confirm our own experience in a limited study using oral levodopa and decarboxylase inhibitors.2 One important aspect of the on–off phenomenon in patients with Parkinson's disease treated with levodopa is that, with rare exceptions, it does not appear early in the treatment course. If protein in the food interfering with the transport or uptake of dopamine were a key factor in the genesis of the phenomenon, one would expect.

Original languageEnglish (US)
Pages (from-to)192-194
Number of pages3
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jul 19 1984

ASJC Scopus subject areas

  • Medicine(all)


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