One year treatment with haloperidol or clozapine fails to alter neostriatal D1- and D2-dopamine receptor sensitivity in the rat

Charles R. Ashby, Robert Hitzemann, Joan E. Rubinstein, R. Y. Wang

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Rats were treated continuously with either haloperidol (HAL), clozapine (CLOZ) or tap water for one year. There were no differences between age-matched control and antipsychotic drug (APD) treated groups regarding the effects of the D1-agonist (+)-SKF 38393 or the D2-agonist quinpirole on striatal cAMP content. However, the combination of SKF (10 μM) and quinpirole (1 μM) produced a marked synergistic response in HAL-treated animals as compared to controls. Our data fail to support the hypothesis that APD produce their neurological side effects by inducing D2-receptor hypersensitivity in the basal ganglia. However, the results do suggest that chronic APD treatment alters the interaction between D1- and D2-neostriatal receptors.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalBrain research
Volume493
Issue number1
DOIs
StatePublished - Jul 24 1989

Keywords

  • Antipsychotic drugs
  • Chronic drug treatment
  • Clozapine
  • Cyclic adenosine monophosphate
  • Dopamine receptor subtype
  • Haloperidol
  • Neostriatum
  • Supersensitivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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